南方科技大学知识苑(SUSTech KC): An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus

题名	An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus
作者	Tian, Yuxin 1; Li, Mengjun 2; Yang, Yang 3 ; Li, Chunhui 1; Peng, Yun 3; Yang, Haiyin 1; Zhao, Mengyuan 1; Wu, Pengfei 1; Ruan, Shaobo 1; Huang, Yuanyu 1; Shen, Chenguang 2; Yang, Minghui 1
通讯作者	Huang, Yuanyu; Shen, Chenguang; Yang, Minghui
发表日期	2024-08-01
DOI	10.1016/j.cclet.2023.109270
发表期刊	CHINESE CHEMICAL LETTERS 影响因子和分区
ISSN	1001-8417
EISSN	1878-5964
卷号	35 期号:8
摘要	The monkeypox virus (MPXV) outbreak, declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) in 2022, continues to pose a significant threat due to the absence of vaccines or drugs for MPXV infection. In this study, we developed an mRNA vaccine that expressing the A29L antigen, a specific protein of the intracellular mature virus. Our vaccine utilizes a thermostable ionizable lipid nanoparticle (iLNP) platform and has been administered to mice. Our findings demonstrate that the MPXV A29L mRNA vaccine candidate induces robust cross-neutralizing immune responses against both vaccinia virus (VACV) and MPXV live virus. Furthermore, immunization with the vaccine candidate provided protection against the VACV challenge in mice. These findings underscore the potential of mRNA-LNP vaccines as safe and effective candidates against monkeypox epidemics. Given the current absence of specific interventions for MPXV infection, our study represents a significant step forward in developing a viable solution to combat this ongoing public health threat. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
关键词	Monkeypox virus mRNA vaccine Lipid -nano particle A29L VACV
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	National Key Research & Development Program of China["2021YFA12010 0 0","2021YFC2302400"] ; Beijing Institute of Technology Research Fund Program for Young Scholars[XSQD-6120220072] ; National Natural Science Foundation of China[82371846] ; China Postdoctoral Science Foundation[2022M720438]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:001237219400001
出版者	ELSEVIER SCIENCE INC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788281
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Beijing Inst Technol, Sch Life Sci, Adv Res Inst Multidisciplinary Sci, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China 2.Southern Med Univ, BSL 3 Lab Guangdong, Guangdong Prov Key Lab Trop Dis Res, Sch Publ Hlth,Dept Lab Med, Guangzhou 510280, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, Shenzhen 518112, Peoples R China
推荐引用方式 GB/T 7714	Tian, Yuxin,Li, Mengjun,Yang, Yang,et al. An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus[J]. CHINESE CHEMICAL LETTERS,2024,35(8).
APA	Tian, Yuxin.,Li, Mengjun.,Yang, Yang.,Li, Chunhui.,Peng, Yun.,...&Yang, Minghui.(2024).An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus.CHINESE CHEMICAL LETTERS,35(8).
MLA	Tian, Yuxin,et al."An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus".CHINESE CHEMICAL LETTERS 35.8(2024).