A circular network of adenosine-mediated mitochondrial dysfunction as coregulators of acute myocardial infarction

Liu, Yang1; Xiao, Tianci1; Wang, Zili1; Ou, Yangbin1; Tan, Ying2; Chen, Liting1; Zhou, Na3; Zou, Rongjun4,5

2024

10.7150/ijms.97066

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES   影响因子和分区

1449-1907

This study aims to explore the molecular mechanisms and associated pathways of myocardial infarction (MI). We employed a variety of analytical methods, including Mendelian Randomization (MR) analysis, transcriptome microarray data analysis, gene function and pathway enrichment analysis, untargeted metabolomic mass spectrometry analysis, and gene -metabolite interaction network analysis. The MR analysis results revealed a significant impact of mitochondrial DNA copy number on MI and coronary artery bypass grafting. Transcriptome analysis unveiled numerous differentially expressed genes associated with myocardial ischemia, with enrichment observed in cardiac function and energy metabolism pathways. Metabolomic analysis indicated a significant downregulation of mitochondrial regulation pathways in ischemic myocardium. T500 metabolite quantification analysis identified 90 differential metabolites between MI and Sham groups, emphasizing changes in metabolites associated with energy metabolism. Gene -metabolite interaction network analysis revealed the significant roles of key regulatory molecules such as HIF1A, adenosine, TBK1, ATP, NRAS, and EIF2AK3, in the pathogenesis of myocardial ischemia. In summary, this study provides important insights into the molecular mechanisms of MI and highlights interactions at multiple molecular levels, contributing to the establishment of new theoretical foundations for the diagnosis and treatment of MI.

Myocardial infarction Molecular mechanisms Mendelian Randomization analysis Metabolomic mass spectrometry analysis Transcriptome analysis Gene-metabolite interaction network analysis

SCI

英语

其他

Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine[20241120] ; Research on Fundamentals and Applied Fundamentals of Guangzhou University (Institute) Joint Funding Project["202201020605","202201020650"]

General & Internal Medicine

Medicine, General & Internal

WOS:001232019100001

IVYSPRING INT PUBL

Web of Science

1.Zhongshan Huangpu Peoples Hosp, Tradit Chinese Med Dept, Zhongshan 528429, Guangdong, Peoples R China
2.Southern Univ Sci & Technol SUSTech, Sch Med, Shenzhen, Guangdong, Peoples R China
3.Guangzhou Med Univ, Heart Ctr, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Key Lab Res Struct Birth Defect Dis, Guangzhou 510623, Peoples R China
4.Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou 510405, Guangdong, Peoples R China
5.Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Dept Cardiovasc Surg, Guangzhou 510120, Guangdong, Peoples R China

Liu, Yang,Xiao, Tianci,Wang, Zili,et al. A circular network of adenosine-mediated mitochondrial dysfunction as coregulators of acute myocardial infarction[J]. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,2024,21(7).

Liu, Yang.,Xiao, Tianci.,Wang, Zili.,Ou, Yangbin.,Tan, Ying.,...&Zou, Rongjun.(2024).A circular network of adenosine-mediated mitochondrial dysfunction as coregulators of acute myocardial infarction.INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,21(7).

Liu, Yang,et al."A circular network of adenosine-mediated mitochondrial dysfunction as coregulators of acute myocardial infarction".INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 21.7(2024).