FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma

Liao, Zhanpeng; Fan, Haidong; Weng, Junquan; Zhou, Jieyu; Zheng, Yuyan

2024-05-24

10.1155/2024/8810804

ANALYTICAL CELLULAR PATHOLOGY   影响因子和分区

2210-7177

2210-7185

Head and neck squamous cell carcinoma (HNSCC) poses significant challenges with poor survival rates and limited therapeutic strategies. Our study, using The Cancer Genome Atlas (TCGA) data, assesses cancer-associated fibroblast (CAF) gene signatures' clinical relevance. In our analysis across TCGA tumor types, differential gene expression analysis revealed that fibroblast activation protein (FAP) is upregulated in tumor tissues and associated with poorer survival rates in HNSCC. Furthermore, mechanistic studies employing gene-silencing techniques substantiated that FAP knockout led to a significant decrease in cellular proliferation, invasion, and migration in HNSCC cell lines. Through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, we established that high FAP expression correlates with vital biological processes such as extracellular matrix organization, angiogenesis, and cellular motility. Importantly, FAP was found to regulate these processes by promoting the expression of key proteins involved in epithelial-mesenchymal transition-related pathways. Additionally, our analysis revealed a significant correlation between FAP expression and the expression profiles of immune checkpoint molecules, underscoring its potential role in immune modulation. Collectively, our findings illuminate FAP's pivotal role in HNSCC pathogenesis and its potential as a prognostic biomarker and therapeutic target. This research lays the groundwork for understanding the multifaceted roles and regulatory mechanisms of CAFs in HNSCC, thereby offering valuable perspectives for the development of targeted therapeutic strategies aimed at improving patient outcomes.

SCI

英语

第一 ; 通讯

Shenzhen Science and Technology Project[JCYJ20210324114200001] ; null[81900972]

Oncology ; Cell Biology ; Pathology

Oncology ; Cell Biology ; Pathology

WOS:001236779900001

HINDAWI LTD

Web of Science

Jinan Univ, Shenzhen Peoples Hosp, Southern Univ Sci & Technol, Clin Med Coll 2,Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China

Liao, Zhanpeng,Fan, Haidong,Weng, Junquan,et al. FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma[J]. ANALYTICAL CELLULAR PATHOLOGY,2024,2024.

Liao, Zhanpeng,Fan, Haidong,Weng, Junquan,Zhou, Jieyu,&Zheng, Yuyan.(2024).FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma.ANALYTICAL CELLULAR PATHOLOGY,2024.

Liao, Zhanpeng,et al."FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma".ANALYTICAL CELLULAR PATHOLOGY 2024(2024).