南方科技大学知识苑(SUSTech KC): Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin

题名	Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin
作者	Hu, H.1,2 ; Tong, K.3; Tsang, J. Y.3; Ko, C. W.3; Tam, F.4; Loong, T. C.5; Tse, G. M.3,6
通讯作者	Tse, G. M.
发表日期	2024-04-01
DOI	10.1016/j.esmoop.2024.102993
发表期刊	ESMO OPEN 影响因子和分区
EISSN	2059-7029
卷号	9 期号:4
摘要	Background: Triple-negative breast cancer (TNBC) subtyping by gene profiling has provided valuable clinical information. Here, we aimed to evaluate the relevance of TNBC subtyping using immunohistochemistry (IHC), which could be a more clinically practical approach, for prognostication and applications in patient management. Methods: A total of 123 TNBC cases were classified using androgen receptor (AR), CD8, Forkhead box C1 protein (FOXC1), and doublecortin-like kinase 1 (DCLK1) into luminal androgen receptor (LAR), basal-like immunosuppressive (BLIS), mesenchymal-like (MES), and immunomodulatory (IM) subtypes. The IM cases were further divided into the IM-excluded and IM-inflamed categories by CD8 spatial distribution. Their clinicopathological and biomarker profiles and prognoses were evaluated. Results: LAR (28.6%) and MES (11.2%) were the most and least frequent subtypes. The IHC-TNBC subtypes demonstrated distinct clinicopathological features and biomarker profiles, corresponding to the reported features in gene profiling studies. IM-inflamed subtype had the best outcome, while BLIS had a significantly poorer survival. Differential breast-specific marker expressions were found. Trichorhinophalangeal syndrome type 1 (TRPS1) was more sensitive for IM-inflamed and BLIS, GATA-binding protein 3 (GATA3) for IM-excluded and MES, and gross cystic disease fluid protein 15 (GCDFP15) for LAR subtypes. Conclusions: Our findings demonstrated the feasibility of IHC surrogates to stratify TNBC subtypes with distinct features and prognoses. The IM subtype can be refined by its CD8 spatial pattern. Breast-specific marker expression varied among the subtypes. Marker selection should be tailored accordingly.
关键词	triple-negative breast cancers surrogate subtyping clinicopathological features breast markers
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	Health and medical research fund[08190586] ; CUHK direct grant[2020.004] ; Shenzhen Key Medical Discipline Construction Fund[SZXK015]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:001234882200001
出版者	ELSEVIER
来源库	Web of Science
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788327
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Shenzhen Peoples Hosp,Clin Med Coll 2, Div Breast Surg, Dept Gen Surg, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China 3.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, State Key Lab Translat Oncol, Hong Kong, Peoples R China 4.Kwong Wah Hosp, Dept Pathol, Hong Kong, Peoples R China 5.Tuen Mun Hosp, Dept Pathol, Hong Kong, Peoples R China 6.Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Ngan Shing St, Hong Kong, Peoples R China
第一作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Hu, H.,Tong, K.,Tsang, J. Y.,et al. Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin[J]. ESMO OPEN,2024,9(4).
APA	Hu, H..,Tong, K..,Tsang, J. Y..,Ko, C. W..,Tam, F..,...&Tse, G. M..(2024).Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin.ESMO OPEN,9(4).
MLA	Hu, H.,et al."Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin".ESMO OPEN 9.4(2024).