Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis

Li, Cunzi1; Zhou, Lan2,3; Sun, Hongyan2; Yang, Ming Ming2

2024

10.2147/CIA.S463297

CLINICAL INTERVENTIONS IN AGING   影响因子和分区

1178-1998

Age -related macular degeneration (AMD) is a degenerative ocular disease primarily affecting central vision in the elderly. Its pathogenesis is complex, involving cellular senescence and immune homeostasis dysregulation. This review investigates the interaction between these two critical biological processes in AMD pathogenesis and their impact on disease progression. Initially, cellular senescence is analyzed, with particular emphasis on retinal damage induced by senescent retinal pigment epithelial cells. Subsequently, the occurrence of immune homeostasis dysregulation within the retina and its mechanistic role in AMD areis explored. Furthermore, the paper also discusses in detail the interplay between cellular senescence and immune responses, forming a vicious cycle that exacerbates retinal damage and may influence treatment outcomes. In summary, a deeper understanding of the interrelation between cellular senescence and immune dysregulation is vital for the developing innovative therapeutic strategies for AMD.

age-related macular degeneration cellular senescence immune homeostasis dysregulation

SCI

英语

通讯

Shenzhen Science and Technology Project[JCYJ20220818102603007] ; General Project of the Shenzhen Natural Science Foundation[JCYJ20210324113808023]

Geriatrics & Gerontology

Geriatrics & Gerontology

WOS:001233791300001

DOVE MEDICAL PRESS LTD

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen 518020, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Ophthalmol,Affiliated Hosp 1,Clin Med Coll 2,, 1017 Dongmen North Rd, Shenzhen 518020, Peoples R China
3.Jinan Univ, Postdoctoral Sci Res Stn Basic Med, Guangzhou 510632, Peoples R China

Li, Cunzi,Zhou, Lan,Sun, Hongyan,et al. Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis[J]. CLINICAL INTERVENTIONS IN AGING,2024,19.

Li, Cunzi,Zhou, Lan,Sun, Hongyan,&Yang, Ming Ming.(2024).Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis.CLINICAL INTERVENTIONS IN AGING,19.

Li, Cunzi,et al."Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis".CLINICAL INTERVENTIONS IN AGING 19(2024).