The Disulfide Bond-Mediated Cyclization of Oral Peptides

Yao, Chenguang1; Ye, Guoguo2,3; Yang, Qin4; Chen, Zhenwang5; Yang, Minghui6,7

2024

10.2174/0113892037280719231214095428

CURRENT PROTEIN & PEPTIDE SCIENCE   影响因子和分区

1389-2037

1875-5550

'Structure determines function' is a consensus in the current biological community, but the structural characteristics corresponding to a certain function have always been a hot field of scientific exploration. A peptide is a bio-active molecule that is between the size of an antibody and a small molecule. Still, the gastrointestinal barrier and the physicochemical properties of peptides have always limited the oral administration of peptides. Therefore, we analyze the main ways oral peptide conversion strategies of peptide modification and permeation enhancers. Based on our analysis of the structure of natural oral peptides, which can be absorbed through the gastrointestinal tract, we believe that the design strategy of natural stapled peptides based on disulfide bonds is good for oral peptide design. This cannot only be used to identify anti-gastrointestinal digestive structural proteins in nature but also provide a solid structural foundation for the construction of new oral peptide drugs.

Oral peptides cyclization aglycin vglycin cell-penetration proteins

SCI

英语

其他

Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

WOS:001228812600007

BENTHAM SCIENCE PUBL LTD

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Hubei Univ Technol, Natl 111 Ctr Cellular Regulat & Mol Pharmaceut, Cooperat Innovat Ctr Ind Fermentat, Minist Educ,Minist Educ & Hubei Prov,Sino German B, Wuhan 430068, Peoples R China
2.Southern Univ Sci & Technol, Hosp 2, Natl Clin Res Ctr Infect Dis,Div Infect Dis,Shenzh, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
4.Wuhan Univ, Coll Life Sci, Wuhan, Peoples R China
5.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Peoples R China
6.Beijing Inst Technol, Sch Life Sci, Adv Res Inst Multidisciplinary Sci, Beijing 100081, Peoples R China
7.Beijing Inst Technol, Key Lab Mol Med & Biotherapy, Key Lab Med Mol Sci & Pharmaceut Engn, Beijing 100081, Peoples R China

Yao, Chenguang,Ye, Guoguo,Yang, Qin,et al. The Disulfide Bond-Mediated Cyclization of Oral Peptides[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2024,25(6).

Yao, Chenguang,Ye, Guoguo,Yang, Qin,Chen, Zhenwang,&Yang, Minghui.(2024).The Disulfide Bond-Mediated Cyclization of Oral Peptides.CURRENT PROTEIN & PEPTIDE SCIENCE,25(6).

Yao, Chenguang,et al."The Disulfide Bond-Mediated Cyclization of Oral Peptides".CURRENT PROTEIN & PEPTIDE SCIENCE 25.6(2024).