Toripalimab plus cetuximab combined with radiotherapy in a locally advanced platinum-based chemotherapy-insensitive nasopharyngeal carcinoma patient: a case report

Piao, Ying1; Yang, Yao1; Wu, Shihai1; Han, Ling2

2024-05-10

10.3389/fonc.2024.1383250

FRONTIERS IN ONCOLOGY   影响因子和分区

2234-943X

Background Locoregionally advanced nasopharyngeal carcinoma (NPC) is an epithelial malignancy that primarily occurs in East and Southeast Asia, and it is associated with relatively poor overall survival (OS). Currently, there is no reliably effective standard treatment for NPC that progresses after first-line therapy with platinum-based chemotherapy.Case report A 55-year-old woman diagnosed with stage IVa NPC received two cycles of platinum-based chemotherapy but encountered an increase in the size of cervical lymph nodes and suffered from adverse events. The patient was then switched to toripalimab plus cetuximab combined with radical radiotherapy and had a complete clinical response within 2 months following the completion of radiotherapy without severe treatment-related adverse events.Conclusion This case report showed that toripalimab plus cetuximab combined with radiotherapy for the treatment of patients with locoregionally advanced nasopharyngeal carcinoma may result in a fast and durable response with a manageable safety profile.

nasopharyngeal carcinoma toripalimab cetuximab radiotherapy platinum-insensitive

SCI

英语

第一 ; 通讯

Oncology

Oncology

WOS:001229862100001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Radiat Oncol,Clin Med Coll, Shenzhen, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Otorhinolaryngol,Clin Med C, Shenzhen, Peoples R China

Piao, Ying,Yang, Yao,Wu, Shihai,et al. Toripalimab plus cetuximab combined with radiotherapy in a locally advanced platinum-based chemotherapy-insensitive nasopharyngeal carcinoma patient: a case report[J]. FRONTIERS IN ONCOLOGY,2024,14.

Piao, Ying,Yang, Yao,Wu, Shihai,&Han, Ling.(2024).Toripalimab plus cetuximab combined with radiotherapy in a locally advanced platinum-based chemotherapy-insensitive nasopharyngeal carcinoma patient: a case report.FRONTIERS IN ONCOLOGY,14.

Piao, Ying,et al."Toripalimab plus cetuximab combined with radiotherapy in a locally advanced platinum-based chemotherapy-insensitive nasopharyngeal carcinoma patient: a case report".FRONTIERS IN ONCOLOGY 14(2024).