Sex difference in nocturnal blood pressure dipping in adolescents with varying degrees of adiposity

Zhou, Yi1,2,3; Zhao, Lin3,4; Zhang, Zenglei3; Meng, Xu3; Cai, Qiu-jing5; Zhao, Xiao-lei5; Wang, Lin-ping3; Hu, Ai-hua5; Zhou, Xian-liang3

2024-05-22

10.1186/s12887-024-04804-0

BMC PEDIATRICS   影响因子和分区

1471-2431

Background For adolescents, abnormal dipping patterns in blood pressure (BP) are associated with early-onset organ damage and a higher risk of cardiovascular disorders in adulthood. Obesity is one of the most common reasons for abnormal BP dipping in young people. However, it is unknown whether the severity of obesity is associated with BP dipping status and whether this association is sex-dependent. Methods 499 participants between 12 and 17 years old with overweight or obesity underwent ambulatory blood pressure monitoring (ABPM) between April 2018 and January 2019 in Beijing and Baoding. Participants were grouped by body mass index (BMI) into overweight (BMI 85th-95th percentile), obese (BMI >= 95th percentile) and severely obese (BMI >= 120% of 95th percentile or >= 35 kg/m2) groups. Non-dipping was defined as a < 10% reduction in BP from day to night. The interaction effect between sex and obesity degree was also analyzed. Results 326 boys and 173 girls were included, of whom 130 were overweight, 189 were obese, and 180 were severely obese. Girls with severe obesity had a higher prevalence of non-dipping, but boys showed no significant differences in BP dipping status between obesity categories. In addition, as obesity severity went up, a more evident increase in night-time SBP was observed in girls than in boys. Conclusions Severely obese is associated with a higher prevalence of non-BP dipping patterns in girls than in boys, which suggests that the relationship between the severity of obesity and BP dipping status might be sex-specific.

Ambulatory blood pressure monitor Adolescents Dipping patterns Obesity severity Sex difference

SCI

英语

其他

National Key Research and Development Program of China[2016YFC1300100] ; CAMS Innovation Fund for Medical Sciences[2022-I2M-CT-A-010]

Pediatrics

Pediatrics

WOS:001229420300003

BMC

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Shenzhen Cardiovasc Minimally Invas Med Engn Techn, Clin Med Coll 2,Dept Cardiol, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Echocardiog, Beijing 100037, Peoples R China
4.China Japan Friendship Hosp, Natl Integrated Tradit & Western Med Ctr Cardiovas, Beijing, Peoples R China
5.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Noncommunicable Dis Management, Beijing, Peoples R China

Zhou, Yi,Zhao, Lin,Zhang, Zenglei,et al. Sex difference in nocturnal blood pressure dipping in adolescents with varying degrees of adiposity[J]. BMC PEDIATRICS,2024,24(1).

Zhou, Yi.,Zhao, Lin.,Zhang, Zenglei.,Meng, Xu.,Cai, Qiu-jing.,...&Zhou, Xian-liang.(2024).Sex difference in nocturnal blood pressure dipping in adolescents with varying degrees of adiposity.BMC PEDIATRICS,24(1).

Zhou, Yi,et al."Sex difference in nocturnal blood pressure dipping in adolescents with varying degrees of adiposity".BMC PEDIATRICS 24.1(2024).