Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance

Jia, Yanhui1,2; He, Zhi1; Liu, Fangchao1; Li, Jianxin1; Liang, Fengchao3; Huang, Keyong1; Chen, Jichun1; Cao, Jie1; Li, Hongfan1; Shen, Chong4; Yu, Ling5; Liu, Xiaoqing6,7; Hu, Dongsheng8,9; Huang, Jianfeng1; Zhao, Yingxin10; Liu, Yang11; Lu, Xiangfeng1; Gu, Dongfeng1,12; Chen, Shufeng1

2024-04-01

10.1016/j.envint.2024.108626

ENVIRONMENT INTERNATIONAL   影响因子和分区

0160-4120

1873-6750

The relationship of fine particulate matter (PM2.5) exposure and insulin resistance remains inclusive. Our study aimed to investigate this association in the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). Specifically, we examined the associations between long-term PM2.5 exposure and three surrogate indicators of insulin resistance: the triglyceride-glucose index (TyG), TyG with waist circumference (TyG-WC) and metabolic score for insulin resistance (METS-IR). Additionally, we explored potential effect modification of dietary intake and components. Generalized estimating equations were used to evaluate the associations between PM2.5 and the indicators with an unbalanced repeated measurement design. Our analysis incorporated a total of 162,060 observations from 99,329 participants. Each 10 mu g/m(3) increment of PM2.5 was associated with an increase of 0.22 % [95 % confidence interval (CI): 0.20 %, 0.25 %], 1.60 % (95 % CI: 1.53 %, 1.67 %), and 2.05 % (95 % CI: 1.96 %, 2.14 %) in TyG, TyG-WC, and METS-IR, respectively. These associations were attenuated among participants with a healthy diet, particularly those with sufficient intake of fruit and vegetable, fish or tea (pinteraction < 0.0028). For instance, among participants with a healthy diet, TyG increased by 0.11 % (95 % CI: 0.08 %, 0.15 %) per 10 mu g/m(3) PM2.5 increment, significantly lower than the association observed in those with an unhealthy diet. The findings of this study emphasize the potential of a healthy diet to mitigate these associations, highlighting the urgency for improving air quality and implementing dietary interventions among susceptible populations in China.

Fine particulate matter Healthy diet Insulin resistance Triglyceride-glucose index Metabolic score for insulin resistance Effect modification

SCI ; EI

英语

其他

National Natural Science Foundation of China["82373676","82070473","82030102","82073658","82003549"] ; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences["2021-I2M-1-010","2021-I2M-1-008"] ; National Key Research and Development Program of China[2018YFE0115300] ; National High Level Hospital Clinical Research Funding of China["2022-GSP-GG- 1","2022-GSP-GG-2"]

Environmental Sciences & Ecology

Environmental Sciences

WOS:001230593400001

PERGAMON-ELSEVIER SCIENCE LTD

ENVIRONMENT/ECOLOGY

Web of Science

1.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis,Key Lab Cardiovasc Epidemi, Dept Epidemiol,State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China
2.Tsinghua Univ, Vanke Sch Publ Hlth, Beijing 100084, Peoples R China
3.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen 518055, Peoples R China
4.Nanjing Med Univ, Sch Publ Hlth, Nanjing 211166, Peoples R China
5.Fujian Prov Hosp, Dept Cardiol, Fuzhou 350014, Peoples R China
6.Guangdong Prov Peoples Hosp, Div Epidemiol, Guangzhou 510080, Peoples R China
7.Cardiovasc Inst, Guangzhou 510080, Peoples R China
8.Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou 450001, Peoples R China
9.Shenzhen Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Shenzhen 518060, Peoples R China
10.Shandong First Med Univ, Shandong Acad Med Sci, Inst Basic Med, Cardiocerebrovasc Control & Res Ctr, Jinan 271099, Peoples R China
11.Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, Georgia
12.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen 518055, Peoples R China

Jia, Yanhui,He, Zhi,Liu, Fangchao,et al. Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance[J]. ENVIRONMENT INTERNATIONAL,2024,186.

Jia, Yanhui.,He, Zhi.,Liu, Fangchao.,Li, Jianxin.,Liang, Fengchao.,...&Chen, Shufeng.(2024).Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance.ENVIRONMENT INTERNATIONAL,186.

Jia, Yanhui,et al."Dietary intake changes the associations between long-term exposure to fine particulate matter and the surrogate indicators of insulin resistance".ENVIRONMENT INTERNATIONAL 186(2024).