| 题名 | Extracellular vesicles-derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer |
| 作者 | |
| 通讯作者 | Niu, Shiqiong; Huang, Zhijian; Yin, Haofan |
| 发表日期 | 2024-04-19
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| DOI | |
| 发表期刊 | |
| EISSN | 2589-0042
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| 卷号 | 27期号:4 |
| 摘要 | Extracellular vesicles (EVs) were promising circulating biomarkers for multiple diseases, but whether serum EVs-derived proteins could be used as a reliable tumor biomarker for colorectal cancer (CRC) remained inconclusive. In this study, we identified CXCL4 by a 4D data -independent acquisition -based quantitative proteomics assay of serum EVs-derived proteins in 40 individuals and subsequently analyzed serum EVs-derived CXCL4 levels by ELISA in 2 cohorts of 749 individuals. The results revealed that EVs - derived CXCL4 levels were dramatically elevated in CRC patients than in benign colorectal polyp patients or healthy controls (HC). Furthermore, receiver operating characteristic curves revealed that EVs - derived CXCL4 exhibited superior diagnostic performance with area under the curve of 0.948 in the training cohort. Additionally, CXCL4 could effectively distinguish CRC in stage I/II from HC. Notably, CRC patients with high levels of EVs - derived CXCL4 have shorter 2 -year progression -free survival than those with low levels. Overall, our findings demonstrated that serum EVs-derived CXCL4 was a candidate diagnostic and prognostic biomarker for CRC. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| WOS记录号 | WOS:001228770200001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/788384 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Zhongshan City Peoples Hosp, Dept Lab Med, Zhongshan, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Jinan Univ, Dept Lab Med,Clin Med Coll 2,Affiliated Hos 1, Shenzhen, Peoples R China 3.Sun Yat Sen Univ, Affiliated Hosp 7, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China 4.Sun Yat Sen Univ, Affiliated Hosp 7, Dept Pathol, Shenzhen, Guangdong, Peoples R China 5.Sun Yat Sen Univ, Dept Clin Lab, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Guangdong, Peoples R China 6.Sun Yat Sen Univ, Sch Biomed Engn, Guangzhou, Guangdong, Peoples R China 7.Southern Med Univ, Zhujiang Hosp, Dept Lab Med, Guangzhou, Guangdong, Peoples R China 8.Shenzhen Longgang Dist Second Peoples Hosp, Dept Ophtalmol & ENT, Shenzhen, Guangdong, Peoples R China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Xie, Jinye,Xing, Shan,Jiang, Hongbo,et al. Extracellular vesicles-derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer[J]. ISCIENCE,2024,27(4).
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| APA |
Xie, Jinye.,Xing, Shan.,Jiang, Hongbo.,Zhang, Jiaju.,Li, Daxiao.,...&Yin, Haofan.(2024).Extracellular vesicles-derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer.ISCIENCE,27(4).
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| MLA |
Xie, Jinye,et al."Extracellular vesicles-derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer".ISCIENCE 27.4(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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