Thermal-tagging photoacoustic remote sensing flowmetry

Lu, Yun; Sun, Yunxu; Shen, Zhousheng; Xu, Xiaochuan; Ma, Ting; Peng, Chang; Li, Fenfang1; Ning, Chengqing2; Wang, Jiawei; Liu, Shutian3; Liu, Zhengjun3,5; Xu, Lingji4,5,6,7; Liu, Wei1,6,8

2024-04-01

10.1364/OL.521564

OPTICS LETTERS   影响因子和分区

0146-9592

1539-4794

Ultrasound coupling is one of the critical challenges for traditional photoacoustic (or optoacoustic) microscopy (PAM) techniques transferred to the clinical examination of chronic wounds and open tissues. A promising alternative potential solution for breaking the limitation of ultrasound coupling in PAM is photoacoustic remote sensing (PARS), which implements all -optical non-interferometric photoacoustic measurements. Functional imaging of PARS microscopy was demonstrated from the aspects of histopathology and oxygen metabolism, while its performance in hemodynamic quantification remains unexplored. In this Letter, we present an all -optical thermal -tagging flowmetry approach for PARS microscopy and demonstrate it with comprehensive mathematical modeling and ex vivo and in vivo experimental validations. Experimental results demonstrated that the detectable range of the blood flow rate was from 0 to 12 mm/s with a high accuracy (measurement error: +/- 1.2%) at 10 -kHz laser pulse repetition rate. The proposed all -optical thermaltagging flowmetry offers an effective alternative approach for PARS microscopy realizing non -contact dye -free hemodynamic imaging. (c) 2024 Optica Publishing Group

SCI ; EI

英语

其他

Special Project for Marine Economy Development of Guang-dong Province[GDNRC2022-19] ; National Natural Science Foun-dation of China["62205089","12374271"] ; Basic and Applied Basic Research Foundation of Guangdong Province[2021A1515110030] ; Guang-dong Provincial Quantum Science Strategic Initiative[GDZX2304006] ; Guangdong Provincial Pearl River Talents Program[2021QN02X179] ; Science, Technology and Innovation Commission of Shenzhen Municipality["GXWD20231130143453003","JCYJ20220531095604009","RCYX20221008092907027","SGDX20220530111403022"]

Optics

Optics

WOS:001228593700001

Optica Publishing Group

PHYSICS

Web of Science

1.Harbin Inst Technol, Sch Elect & Informat Engn, Shenzhen, Peoples R China
2.ShanghaiTech Univ, Ultrasound Bioengn & Instrumentat Lab, Shanghai, Peoples R China
3.Shenzhen Bay Lab, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen, Peoples R China
5.Harbin Inst Technol, Sch Phys, Harbin, Peoples R China
6.Sun Yat Sen Univ, Sch Ocean Engn & Technol, Zhuhai, Peoples R China
7.Southern Marine Sci & Engn Guangdong Lab Zhuhai, Zhuhai, Peoples R China
8.Quantum Sci Ctr, Guangdong HongKong Macao Greater Bay Area, Shenzhen, Peoples R China

Lu, Yun,Sun, Yunxu,Shen, Zhousheng,et al. Thermal-tagging photoacoustic remote sensing flowmetry[J]. OPTICS LETTERS,2024,49(7).

Lu, Yun.,Sun, Yunxu.,Shen, Zhousheng.,Xu, Xiaochuan.,Ma, Ting.,...&Liu, Wei.(2024).Thermal-tagging photoacoustic remote sensing flowmetry.OPTICS LETTERS,49(7).

Lu, Yun,et al."Thermal-tagging photoacoustic remote sensing flowmetry".OPTICS LETTERS 49.7(2024).