The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms

Huang, Mingyue1; Dai, Junfei1; Zhong, Xianliang2; Wang, Jin2; Xu, Jianzhong2; Du, Bo2

2024

10.32604/biocell.2024.050097

BIOCELL   影响因子和分区

0327-9545

1667-5746

Chronic subdural hematoma (CSDH) is a disease characterized by capsuled blood products that progressively occupy the intracranial space, causing intracranial hypertension and compression in the brain. CSDH frequently occurs in all demographics, especially in the elderly, but the pathogenesis of CSDH remains unclear. In this review, we discuss the origin, development, and current treatment strategies of CSDH. For the fi rst time, we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation, a complex early -stage interactive event in hematoma pathogenesis. We hypothesize that in patients with CSDH, dural border cells (DBCs) might be induced to synthesize collagen or serum proteins might accumulate at the dura and arachnoid layers at the site of injury, thereby encapsulating the hemorrhage. Membrane formation may trigger inflammatory fl ammatory responses after subdural hemorrhage, promoting fi broblast -involved extracellular matrix (ECM) deposition and aberrant angiogenesis within the outer membrane. Consequently, ECM deposition and angiogenesis mutually influence fl uence each other and are modulated by inflammatory fl ammatory processes. By illustrating the complex and interactive mechanism of neomembrane formation, we aim to provide a novel insight into CSDH pathogenesis and propose directions for future research as well as advancements in treatment strategies for this disease.

Chronic subdural hematoma Inflammation Angiogenesis Extracellular matrix Hyperfibrinolysis

SCI

英语

第一 ; 通讯

GuangdongNatural Science Foundation[2020A1515010289] ; null[JSGG20211029095400001]

Life Sciences & Biomedicine - Other Topics

Biology

WOS:001223554500001

TECH SCIENCE PRESS

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Emergency,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518055, Peoples R China

Huang, Mingyue,Dai, Junfei,Zhong, Xianliang,et al. The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms[J]. BIOCELL,2024,48(6).

Huang, Mingyue,Dai, Junfei,Zhong, Xianliang,Wang, Jin,Xu, Jianzhong,&Du, Bo.(2024).The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms.BIOCELL,48(6).

Huang, Mingyue,et al."The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms".BIOCELL 48.6(2024).