Association between viral infection and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis

Guo, Xin1; Ma, Defei1; Li, Rui1; Zhang, Ruolin2; Guo, Yanping3; Yu, Zhangbin4; Chen, Cheng1

2024-07-01

10.1007/s00431-024-05565-9

EUROPEAN JOURNAL OF PEDIATRICS   影响因子和分区

0340-6199

1432-1076

Bronchopulmonary dysplasia (BPD) is the most common serious complication of very preterm infants (VPI) or very low birth weight (VLBW) infants. Studies implicate viral infections in etiopathogenesis. The aim of this study was to summarize the relationship between viral infections and BPD through a systematic review and meta-analysis. We searched PubMed, Embase, the Web of Science Core Collection, and the Cochrane Database on December 19, 2023. We included observational studies that examined the association between viral infections and BPD in preterm infants. We extracted data on study methods, participant characteristics, exposure assessment, and outcome measures. We assessed study risk of bias using the Newcastle-Ottawa Scale (NOS). We included 17 and 15 studies in the qualitative review and meta-analysis, respectively. The meta-analysis showed a significant association between viral infection and BPD diagnosed at 36 weeks postmenstrual age (odds ratio (OR): 2.42, 95% confidence interval: 1.89-3.09, 13 studies, very low certainty of evidence). In a subgroup analysis of specific viruses, cytomegalovirus (CMV) proved to be significantly associated with BPD diagnosed at 36 weeks postmenstrual age (OR: 2.34, 95% confidence interval: 1.80-3.05, 11 studies). We did not find an association between viral infection and BPD diagnosed on the 28th day of life, probably due to the small sample size of the included prospective studies. Conclusion: Viral infections, especially CMV, are associated with an increased risk of BPD in preterm infants. Methodologically reliable prospective studies with large samples are needed to validate our conclusions, and high-quality randomized controlled studies are needed to explore the effect of prevention or treatment of viral infections on the incidence of BPD. What is Known: center dot Studies have attempted to identify viral infections and bronchopulmonary dysplasia in preterm infants; however, results have been inconsistent. What is New: center dot Systematic demonstration that viral infections, particularly cytomegalovirus, are positively associated with bronchopulmonary dysplasia diagnosed in preterm infants at the 36th week of postmenstrual age. center dot The importance of screening for viral infections in preterm infants, especially cytomegalovirus. More high-quality studies should be produced in the future to investigate the causal relationship between viral infections and bronchopulmonary dysplasia.

Bronchopulmonary dysplasia Viruses Preterm infants Viral infections Cytomegalovirus

SCI

英语

通讯

Pediatrics

Pediatrics

WOS:001205478100004

SPRINGER

CLINICAL MEDICINE

Web of Science

1.Shantou Univ, Longgang Dist Matern & Child Healthcare Hosp Shenz, Longgang Matern & Child Inst, Dept Neonatol,Med Coll, Shenzhen 518172, Guangdong, Peoples R China
2.Nanshan Matern & Child Healthcare Hosp, Dept Neonatol, Shenzhen 518067, Guangdong, Peoples R China
3.Peking Univ Shenzhen Hosp, Dept Pediat, Shenzhen 518036, Guangdong, Peoples R China
4.Clin Med Coll 2, Southern Univ Sci & Technol, Dept Neonatol,Shenzhen Peoples Hosp, Dept Neonatol,Shenzhen Peoples Hosp,Jinan Univ, Shenzhen 518000, Guangdong, Peoples R China

Guo, Xin,Ma, Defei,Li, Rui,et al. Association between viral infection and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis[J]. EUROPEAN JOURNAL OF PEDIATRICS,2024,183(7).

Guo, Xin.,Ma, Defei.,Li, Rui.,Zhang, Ruolin.,Guo, Yanping.,...&Chen, Cheng.(2024).Association between viral infection and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.EUROPEAN JOURNAL OF PEDIATRICS,183(7).

Guo, Xin,et al."Association between viral infection and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis".EUROPEAN JOURNAL OF PEDIATRICS 183.7(2024).