Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease: A dietary salt-intervention trial

Lin, Zhennan1; Li, Jianxin1; Liu, Fangchao1; Cao, Jie1; Chen, Shufeng1; Chen, Jichun1; Huang, Keyong1; Wang, Yaqin1; Li, Hongfan1; Wang, Yan1; Huang, Jianfeng1; Gu, Dongfeng1,2; Lu, Xiangfeng1

2024-05-01

10.1007/s11427-023-2507-9

SCIENCE CHINA-LIFE SCIENCES   影响因子和分区

1674-7305

1869-1889

Individuals with a high degree of salt sensitivity (SS) have a greater risk of cardiovascular disease (CVD), but whether SS fosters CVD by influencing metabolomics homeostasis remains unclear. This study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs, based on the MetaSalt study, which was a dietary salt-intervention trial conducted at four centers in China in 2019. A total of 528 participants were recruited and underwent 3 days of baseline observations, a 10-day low-salt intervention, and a 10-day high-salt intervention. Plasma untargeted metabolomics, lipidomics, and BP measurements were scheduled at each stage. Participants were grouped into extreme SS, moderate SS, and salt-resistant (SR) individuals according to their BP responses to salt. Linear mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial stiffness. Mendelian randomization (MR) analyses were applied to establish the causal pathways among the SS-related metabolites, BP, and CVDs. Among the 713 metabolites, 467 were significantly changed after the high-salt intervention. Among them, the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS groups. Of the remaining nonsalt-related metabolites, the baseline levels of 11 metabolites were related to SS. These 41 metabolites explained 23% of the variance in SS. Moreover, SS and its metabolomics signature were positively correlated with arterial stiffness. MR analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP, indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the cause. Our study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster CVDs. This study provides insight into understanding the biology and targets of SS and its role in CVDs.

salt sensitivity dietary salt intake metabolomics Mendelian randomization cardiovascular disease

SCI

英语

通讯

Life Sciences & Biomedicine - Other Topics

Biology

WOS:001221496100001

SCIENCE PRESS

Web of Science

1.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Dept Epidemiol, Natl Ctr Cardiovasc Dis,Key Lab Cardiovasc Epidemi, Beijing 100037, Peoples R China
2.Southern Univ Sci & Technol, Med Sch, Shenzhen 518055, Peoples R China

Lin, Zhennan,Li, Jianxin,Liu, Fangchao,et al. Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease: A dietary salt-intervention trial[J]. SCIENCE CHINA-LIFE SCIENCES,2024.

Lin, Zhennan.,Li, Jianxin.,Liu, Fangchao.,Cao, Jie.,Chen, Shufeng.,...&Lu, Xiangfeng.(2024).Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease: A dietary salt-intervention trial.SCIENCE CHINA-LIFE SCIENCES.

Lin, Zhennan,et al."Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease: A dietary salt-intervention trial".SCIENCE CHINA-LIFE SCIENCES (2024).