An emerging strategy: probiotics enhance the effectiveness of tumor immunotherapy via mediating the gut microbiome

Jiang, Shuaiming1; Ma, Wenyao1; Ma, Chenchen2; Zhang, Zeng1; Zhang, Wanli1; Zhang, Jiachao1

2024-12-31

10.1080/19490976.2024.2341717

GUT MICROBES   影响因子和分区

1949-0976

1949-0984

The occurrence and progression of tumors are often accompanied by disruptions in the gut microbiota. Inversely, the impact of the gut microbiota on the initiation and progression of cancer is becoming increasingly evident, influencing the tumor microenvironment (TME) for both local and distant tumors. Moreover, it is even suggested to play a significant role in the process of tumor immunotherapy, contributing to high specificity in therapeutic outcomes and long-term effectiveness across various cancer types. Probiotics, with their generally positive influence on the gut microbiota, may serve as effective agents in synergizing cancer immunotherapy. They play a crucial role in activating the immune system to inhibit tumor growth. In summary, this comprehensive review aims to provide valuable insights into the dynamic interactions between probiotics, gut microbiota, and cancer. Furthermore, we highlight recent advances and mechanisms in using probiotics to improve the effectiveness of cancer immunotherapy. By understanding these complex relationships, we may unlock innovative approaches for cancer diagnosis and treatment while optimizing the effects of immunotherapy.

Probiotics tumor immunotherapy gut microbiome tumor microenvironment tumor microbiome

SCI

英语

其他

National Natural Science Foundation of China[32222066] ; National Natural Science Foundation of China[GHYF2023001]

Gastroenterology & Hepatology ; Microbiology

Gastroenterology & Hepatology ; Microbiology

WOS:001216675900001

TAYLOR & FRANCIS INC

Web of Science

1.Hainan Univ, Sch Food Sci & Engn, Haikou 570228, Peoples R China
2.Southern Univ Sci & Technol, Dept Human Cell Biol & Genet, Shenzhen, Peoples R China

Jiang, Shuaiming,Ma, Wenyao,Ma, Chenchen,et al. An emerging strategy: probiotics enhance the effectiveness of tumor immunotherapy via mediating the gut microbiome[J]. GUT MICROBES,2024,16(1).

Jiang, Shuaiming,Ma, Wenyao,Ma, Chenchen,Zhang, Zeng,Zhang, Wanli,&Zhang, Jiachao.(2024).An emerging strategy: probiotics enhance the effectiveness of tumor immunotherapy via mediating the gut microbiome.GUT MICROBES,16(1).

Jiang, Shuaiming,et al."An emerging strategy: probiotics enhance the effectiveness of tumor immunotherapy via mediating the gut microbiome".GUT MICROBES 16.1(2024).