Donor-Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR-II Emission

Yang, Xueqin1,2,3; Wang, Xinyuan1,2,4; Zhang, Xun4; Zhang, Jianyu1,2; Lam, Jacky W. Y.1,2; Sun, Haitao5,6; Yang, Jinglei1,2; Liang, Yongye4; Tang, Ben Zhong1,2,7

2024-05-01

10.1002/adma.202402182

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

["Photosensitizers (PSs) with aggregation-induced emission (AIE) characteristics are competitive candidates for bioimaging and therapeutic applications. However, their short emission wavelength and nonspecific organelle targeting hinder their therapeutic effectiveness. Herein, a donor-acceptor modulation approach is reported to construct a series of ionic AIE photosensitizers with enhanced photodynamic therapy (PDT) outcomes and fluorescent emission in the second near-infrared (NIR-II) window. By employing dithieno[3,2-b:2 ',3 '-d]pyrrole (DTP) and indolium (In) as the strong donor and acceptor, respectively, the compound DTP-In exhibits a substantial redshift in absorption and fluorescent emission reach to NIR-II region. The reduced energy gap between singlet and triplet states in DTP-In also increases the reactive oxygen species (ROS) generation rate. Further, DTP-In can self-assemble in aqueous solutions, forming positively charged nanoaggregates, which are superior to conventional encapsulated nanoparticles in cellular uptake and mitochondrial targeting. Consequently, DTP-In aggregates show efficient photodynamic ablation of 4T1 cancer cells and outstanding tumor theranostic in vivo under 660 nm laser irradiation. This work highlights the potential of molecular engineering of donor-acceptor AIE PSs with multiple functionalities, thereby facilitating the development of more effective strategies for cancer therapy.","An aggregation induced emission photosensitizer, DTP-In, is constructed with strong dithieno[3,2-b:2 ',3 '-d]pyrrole (DTP) donor and indolium (In) acceptor, achieving redshift in absorption and emission wavelength and enhanced reactive oxygen species (ROS) generation rate simultaneously. DTP-In can self-assemble into positively charged nanoaggregates in aqueous solutions and specifically target to the mitochondria, leading to enhanced photodynamic therapy effect under 660 nm laser irradiation. image"]

aggregation-induced emission donor-acceptor modulating mitochondria-targeting near-infrared emission photodynamic therapy

SCI ; EI

英语

通讯

Shenzhen Fundamental Research Funding (Key Program)[JCYJ20200109141405950] ; Innovation and Technology Commission["ITC-CNERC14SC01","ITCPD/17-9"] ; Shenzhen Key Laboratory of Functional Aggregate Materials[ZDSYS20211021111400001] ; Science Technology Innovation Commission of Shenzhen Municipality["KQTD20210811090142053","JCYJ20220818103007014"] ; null[16303221] ; null[(C6014-20 W)]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001216974700001

WILEY-V C H VERLAG GMBH

20241816025874

Cancer cells ; Cell proliferation ; Diseases ; Fluorescence ; Infrared devices ; Photodynamic therapy ; Photosensitizers

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Light/Optics:741.1

MATERIALS SCIENCE

Web of Science

1.Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Div Life Sci, State Key Lab Mol Neurosci,Dept Chem,Hong Kong Bra, Clear Water Bay, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Clear Water Bay, Hong Kong, Peoples R China
3.Hong Kong Univ Sci & Technol Guangzhou, Biosci & Biomed Engn Thrust, Syst Hub, Guangzhou 511400, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
5.East China Normal Univ, Sch Phys & Elect Sci, State Key Lab Precis Spect, Shanghai 200241, Peoples R China
6.Shanxi Univ, Collaborat Innovat Ctr Extreme Opt, Taiyuan 030006, Shanxi, Peoples R China
7.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen CUHK Shenzhen, Shenzhen 518172, Guangdong, Peoples R China

Yang, Xueqin,Wang, Xinyuan,Zhang, Xun,et al. Donor-Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR-II Emission[J]. ADVANCED MATERIALS,2024,36.

Yang, Xueqin.,Wang, Xinyuan.,Zhang, Xun.,Zhang, Jianyu.,Lam, Jacky W. Y..,...&Tang, Ben Zhong.(2024).Donor-Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR-II Emission.ADVANCED MATERIALS,36.

Yang, Xueqin,et al."Donor-Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR-II Emission".ADVANCED MATERIALS 36(2024).