南方科技大学知识苑(SUSTech KC): Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review

题名	Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review
作者	Zhao, Fang 1 ; Lu, Hongzhou 3
通讯作者	Lu, Hongzhou
发表日期	2024-04-01
DOI	10.5582/bst.2024.01062
发表期刊	BIOSCIENCE TRENDS 影响因子和分区
ISSN	1881-7815
EISSN	1881-7823
卷号	18 期号:2
摘要	Antiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real -world studies have demonstrated the favorable renal safety profile of ART regimens incorporating TAF for PWH. This paper seeks to consolidate the available evidence regarding the renal safety of TAF-based regimens in PWH, encompassing both the general PWH and those with renal impairment or predisposing factors, in order to offer recommendations and insights for TAF clinical application.
关键词	people with HIV (PWH) tenofovir alafenamide (TAF) renal safety
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一
资助项目	Shenzhen Science and Technology Program[JCYJ20220530163212029]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:001216615200001
出版者	IRCA-BSSA
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788492
专题	南方科技大学第二附属医院
作者单位	1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Guangdong, Peoples R China 3.Shenzhen Third Peoples Hosp, Natl Clin Res Ctr Infect Dis, Dept Infect Dis, Shenzhen 518112, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Zhao, Fang,Lu, Hongzhou. Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review[J]. BIOSCIENCE TRENDS,2024,18(2).
APA	Zhao, Fang,&Lu, Hongzhou.(2024).Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review.BIOSCIENCE TRENDS,18(2).
MLA	Zhao, Fang,et al."Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review".BIOSCIENCE TRENDS 18.2(2024).