Causal associations of cognition, intelligence, education, health and lifestyle factors with cervical spondylosis: a mendelian randomization study

Ren, Zhenxiao1,2; Cheng, Xing2,3; Xu, Jinghui2; Niu, Tianzuo2; Long, Houqing1

2024-04-25

10.3389/fgene.2024.1297213

FRONTIERS IN GENETICS   影响因子和分区

1664-8021

Background: Education, cognition, and intelligence are phenotypically and genetically related. Education has been shown to have a protective effect on the risk of developing cervical spondylosis. However, it is unclear whether cognition and intelligence have independent causal effects on cervical spondylosis, and whether health and lifestyle factors influence this association. Methods: We first assessed the independent effects of education, cognition, and intelligence on cervical spondylosis by two-sample Mendelian randomization and multivariable Mendelian randomization analysis, and evaluated 26 potential association mediators using two-step Mendelian randomization, and calculated the median proportion. Results: The results showed that only education had an independent causal effect on cervical spondylosis, and had a protective effect on the risk of cervical spondylosis (beta: 0.3395; se: 0.166; p < 0.05; OR:0.71; [95%CI: 0.481-0.943]. Of the 26 potential associated mediators, a factor was identified: SHBG (mediated proportion: 2.5%). Univariable Mendelian randomization results showed that the risk factors for cervical spondylosis were time spent watching TV (OR:1.96; [95%CI: 1.39-2.76]), smoking (OR:2.56; [95%CI: 1.061-1.486]), body mass index (OR:1.26; [95%CI: 1.124-1.418]), percentage of body fat (OR:1.32; [95%CI: 1.097-1.593]), major depression (OR:1.27; [95%CI: 1.017-1.587]) and sitting height (OR:1.15; [95%CI: 1.025-1.291]). Protective factors include computer using (OR:0.65; [95%CI: 0.418-0.995]), sex hormone binding globulin (OR:0.87; [95%CI: 0.7955-0.951]) and high-density lipoprotein (OR:0.90; [95%CI: 0.826-0.990]). Conclusion: Our findings demonstrate the causal and independent effects of education on cervical spondylosis and suggest that lifestyle media may be a priority target for the prevention of cervical spondylosis due to low educational attainment.

cervical spondylosis mendelian randomization mediation analyses education sex hormone binding globulin

SCI

英语

第一 ; 通讯

Natural Science Foundation of China[82201360] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110188]

Genetics & Heredity

Genetics & Heredity

WOS:001215920500001

FRONTIERS MEDIA SA

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp,Affiliated Hosp 1, Clin Med Coll 2,Dept Spine Surg Orthopaed, Shenzhen, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Spine Surg, Guangdong Prov Key Lab Orthopaed & Traumatol, Guangzhou, Guangdong, Peoples R China
3.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Spine Surg,Orthoped Ctr, Guangzhou, Guangdong, Peoples R China

Ren, Zhenxiao,Cheng, Xing,Xu, Jinghui,et al. Causal associations of cognition, intelligence, education, health and lifestyle factors with cervical spondylosis: a mendelian randomization study[J]. FRONTIERS IN GENETICS,2024,15.

Ren, Zhenxiao,Cheng, Xing,Xu, Jinghui,Niu, Tianzuo,&Long, Houqing.(2024).Causal associations of cognition, intelligence, education, health and lifestyle factors with cervical spondylosis: a mendelian randomization study.FRONTIERS IN GENETICS,15.

Ren, Zhenxiao,et al."Causal associations of cognition, intelligence, education, health and lifestyle factors with cervical spondylosis: a mendelian randomization study".FRONTIERS IN GENETICS 15(2024).