Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration

Liu, Lei1; Wang, Wantao1,2,3; Huang, Lin1; Xian, Yiwen1; Ma, Wenzheng1,2,3; Zhao, Lei1; Li, Yixi1; Zheng, Zhaomin2,3; Liu, Hongmei1; Wu, Decheng1

2024-04-01

10.1002/adhm.202400717

ADVANCED HEALTHCARE MATERIALS   影响因子和分区

2192-2640

2192-2659

["Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential in the treatment of IDD by facilitating localized and controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation of IDD, is developed. The gelatin methacryloyl is functionalized with phenylboronic acid groups to enhance drug loading capacity and enable dual stimuli-responsive behavior, while the incorporation of oxidized hyaluronic acid further improves the adhesive properties. The prepared hydrogel exhibits an enhanced drug loading capacity for diol-containing drugs, pH- and reactive oxygen species (ROS)-responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, and favorable biocompatibility. Furthermore, the hydrogel shows a beneficial protective efficacy on NP cells within an in vitro oxidative stress microenvironment. The in vivo results demonstrate the hydrogel's excellent therapeutic effect on treating IDD by maintaining water retention, restoring disc height, and promoting NP regeneration, indicating that this hydrogel holds great potential as a promising therapeutic approach for regulating the microenvironment and alleviating the progression of IDD.","In this work, an injectable dual stimuli-responsive adhesive hydrogel exhibits enhanced drug loading capacity for diol-containing drugs, pH- and reactive oxygen species (ROS)-responsive behavior, excellent radical scavenging efficiency, favorable biocompatibility, beneficial protective efficacy on NP cells in an oxidative stress microenvironment in vitro, as well as excellent therapeutic effect in treating IDD in vivo. image"]

boronic ester bonds inflammation-responsive injectable hydrogels intervertebral disc degeneration

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[21935011] ; Shenzhen Science and Technology Innovation Commission["KQTD20200820113012029","JCYJ20220818100601003","JCYJ20220530114409020","20231115134555001"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; null[2020YFA0908900]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:001214482400001

WILEY

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Spine Surg, Guangzhou 510080, Peoples R China
3.Sun Yat Sen Univ, Pain Res Ctr, Guangzhou 510080, Peoples R China

Liu, Lei,Wang, Wantao,Huang, Lin,et al. Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration[J]. ADVANCED HEALTHCARE MATERIALS,2024.

Liu, Lei.,Wang, Wantao.,Huang, Lin.,Xian, Yiwen.,Ma, Wenzheng.,...&Wu, Decheng.(2024).Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration.ADVANCED HEALTHCARE MATERIALS.

Liu, Lei,et al."Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration".ADVANCED HEALTHCARE MATERIALS (2024).