ORAI Ca²⁺ Channels in Cancers and Therapeutic Interventions

Zhang, Qian; Wang, Chen; He, Lian

2024-04-01

10.3390/biom14040417

BIOMOLECULES   影响因子和分区

2218-273X

The ORAI proteins serve as crucial pore-forming subunits of calcium-release-activated calcium (CRAC) channels, pivotal in regulating downstream calcium-related signaling pathways. Dysregulated calcium homeostasis arising from mutations and post-translational modifications in ORAI can lead to immune disorders, myopathy, cardiovascular diseases, and even cancers. Small molecules targeting ORAI present an approach for calcium signaling modulation. Moreover, emerging techniques like optogenetics and optochemistry aim to offer more precise regulation of ORAI. This review focuses on the role of ORAI in cancers, providing a concise overview of their significance in the initiation and progression of cancers. Additionally, it highlights state-of-the-art techniques for ORAI channel modulation, including advanced optical tools, potent pharmacological inhibitors, and antibodies. These novel strategies offer promising avenues for the functional regulation of ORAI in research and may inspire innovative approaches to cancer therapy targeting ORAI.

CRAC channels store-operated Ca2+ entry ORAI optogenetics cancers

SCI

英语

第一 ; 通讯

Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

WOS:001211133900001

MDPI

Web of Science

Southern Univ Sci & Technol, Sch Med, Dept Pharmacol, Joint Lab Guangdong Hong Kong Univ Vasc Homeostasi, Shenzhen 518055, Peoples R China

Zhang, Qian,Wang, Chen,He, Lian. ORAI Ca²⁺ Channels in Cancers and Therapeutic Interventions[J]. BIOMOLECULES,2024,14(4).

Zhang, Qian,Wang, Chen,&He, Lian.(2024).ORAI Ca²⁺ Channels in Cancers and Therapeutic Interventions.BIOMOLECULES,14(4).

Zhang, Qian,et al."ORAI Ca²⁺ Channels in Cancers and Therapeutic Interventions".BIOMOLECULES 14.4(2024).