南方科技大学知识苑(SUSTech KC): Vacuolar H<SUP>+</SUP>-ATPase in Diabetes, Hypertension, and Atherosclerosis

题名	Vacuolar H⁺-ATPase in Diabetes, Hypertension, and Atherosclerosis
作者	Wang, Na 1,2; Ren, Liwei 1,3; Danser, A. H. Jan 1
通讯作者	Danser, A. H. Jan
发表日期	2024-07-01
DOI	10.1111/micc.12855
发表期刊	MICROCIRCULATION 影响因子和分区
ISSN	1073-9688
EISSN	1549-8719
卷号	31 期号:5
摘要	Vacuolar H+-ATPase (V-ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space. Moreover, V-ATPase has been implicated in receptor-mediated signaling. Although numerous studies have explored the role of V-ATPase in cancer, osteoporosis, and neurodegenerative diseases, research on its involvement in vascular disease remains limited. Vascular diseases pose significant challenges to human health. This review aimed to shed light on the role of V-ATPase in hypertension and atherosclerosis. Furthermore, given that vascular complications are major complications of diabetes, this review also discusses the pathways through which V-ATPase may contribute to such complications. Beginning with an overview of the structure and function of V-ATPase in hypertension, atherosclerosis, and diabetes, this review ends by exploring the pharmacological potential of targeting V-ATPase.
关键词	atherosclerosis-(pro)renin receptor diabetes hypertension V-ATPase
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS研究方向	Hematology ; Cardiovascular System & Cardiology
WOS类目	Hematology ; Peripheral Vascular Disease
WOS记录号	WOS:001209430700001
出版者	WILEY
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788553
专题	南方科技大学第一附属医院
作者单位	1.Erasmus MC, Dept Internal Med, Div Vasc Med & Pharmacol, Rotterdam, Netherlands 2.Shantou Univ, Affiliated Hosp 1, Clin Res Ctr, Med Coll, Shantou, Peoples R China 3.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Pharm,Shenzhen Peoples Hosp,Clin Med Coll 2, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Wang, Na,Ren, Liwei,Danser, A. H. Jan. Vacuolar H⁺-ATPase in Diabetes, Hypertension, and Atherosclerosis[J]. MICROCIRCULATION,2024,31(5).
APA	Wang, Na,Ren, Liwei,&Danser, A. H. Jan.(2024).Vacuolar H⁺-ATPase in Diabetes, Hypertension, and Atherosclerosis.MICROCIRCULATION,31(5).
MLA	Wang, Na,et al."Vacuolar H⁺-ATPase in Diabetes, Hypertension, and Atherosclerosis".MICROCIRCULATION 31.5(2024).