Analysis of differential metabolites in serum metabolomics of patients with aortic dissection

Gong, Yun1,2; Li, Tangzhiming1,2; Liu, Qiyun1,2; Wang, Xiaoyu1,2; Deng, Zixian1,2; Cheng, Lixin1,2; Yu, Biao3; Liu, Huadong1,2

2024-04-25

10.1186/s12872-024-03798-y

BMC CARDIOVASCULAR DISORDERS   影响因子和分区

1471-2261

Background Pathogenesis and diagnostic biomarkers of aortic dissection (AD) can be categorized through the analysis of differential metabolites in serum. Analysis of differential metabolites in serum provides new methods for exploring the early diagnosis and treatment of aortic dissection.Objectives This study examined affected metabolic pathways to assess the diagnostic value of metabolomics biomarkers in clients with AD.Method The serum from 30 patients with AD and 30 healthy people was collected. The most diagnostic metabolite markers were determined using metabolomic analysis and related metabolic pathways were explored.Results In total, 71 differential metabolites were identified. The altered metabolic pathways included reduced phospholipid catabolism and four different metabolites considered of most diagnostic value including N2-gamma-glutamylglutamine, PC(phocholines) (20:4(5Z,8Z,11Z,14Z)/15:0), propionyl carnitine, and taurine. These four predictive metabolic biomarkers accurately classified AD patient and healthy control (HC) samples with an area under the curve (AUC) of 0.9875. Based on the value of the four different metabolites, a formula was created to calculate the risk of aortic dissection. Risk score = (N2-gamma-glutamylglutamine x -0.684) + (PC (20:4(5Z,8Z,11Z,14Z)/15:0) x 0.427) + (propionyl carnitine x 0.523) + (taurine x -1.242). An additional metabolic pathways model related to aortic dissection was explored.Conclusion Metabolomics can assist in investigating the metabolic disorders associated with AD and facilitate a more in-depth search for potential metabolic biomarkers.

Aortic dissection Differential metabolites Metabolic biomarkers Metabolic pathways

SCI

英语

通讯

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:001209743500001

BMC

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen Cardiovasc Minimally Invas Med Engn Techn, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Shenzhen Univ, Affiliated Hosp 3, Shenzhen Luohu Hosp Grp, Luohu Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China

Gong, Yun,Li, Tangzhiming,Liu, Qiyun,et al. Analysis of differential metabolites in serum metabolomics of patients with aortic dissection[J]. BMC CARDIOVASCULAR DISORDERS,2024,24(1).

Gong, Yun.,Li, Tangzhiming.,Liu, Qiyun.,Wang, Xiaoyu.,Deng, Zixian.,...&Liu, Huadong.(2024).Analysis of differential metabolites in serum metabolomics of patients with aortic dissection.BMC CARDIOVASCULAR DISORDERS,24(1).

Gong, Yun,et al."Analysis of differential metabolites in serum metabolomics of patients with aortic dissection".BMC CARDIOVASCULAR DISORDERS 24.1(2024).