A 700 nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis

Dao, Anyi1; Chen, Shiyan2,3; Pan, Li1; Ren, Qingyan4; Wang, Xun4; Wu, Haorui1; Gong, Qiufang5; Chen, Zeduan6; Ji, Shaomin6; Ru, Jiaxi5; Zhu, Haotu7; Liang, Chao5; Zhang, Pingyu4; Xia, Haiping2,3; Huang, Huaiyi1

2024-04-01

10.1002/adhm.202400956

ADVANCED HEALTHCARE MATERIALS   影响因子和分区

2192-2640

2192-2659

["Photoactivable chemotherapy (PACT) using metallic complexes provides spatiotemporal selectivity over drug activation for targeted anticancer therapy. However, the poor absorption in near-infrared (NIR) light region of most metallic complexes renders tissue penetration challenging. Herein, an NIR light triggered dinuclear photoactivable Ru(II) complex (Ru2) is presented and the antitumor mechanism is comprehensively investigated. The introduction of a donor-acceptor-donor (D-A-D) linker greatly enhances the intramolecular charge transition, resulting in a high molar extinction coefficient in the NIR region with an extended triplet excited state lifetime. Most importantly, when activated by 700 nm NIR light, Ru2 exhibits unique slow photodissociation kinetics that facilitates synergistic photosensitization and photocatalytic activity to destroy diverse intracellular biomolecules. In vitro and in vivo experiments show that when activated by 700 nm NIR light, Ru2 exhibits nanomolar photocytotoxicity toward 4T1 cancer cells via the induction of calcium overload and endoplasmic reticulum (ER) stress. These findings provide a robust foundation for the development of NIR-activated Ru(II) PACT complexes for phototherapeutic application.","A dinuclear Ru(II) complex (Ru2) is prepared for enhanced near-infrared light triggered synergetic photosensitization and photocatalytic anticancer therapy. Ru2 generates diverse reactive oxygen species and photocatalytically oxidized coenzyme NAD(P)H and multiple amino acids within cancer cells upon 700 nm LED light irradiation, leading to intracellular redox imbalance and tumor cytoskeleton destruction. image"]

donor-acceptor-donor (D-A-D) linker NIR photoactivated therapy redox imbalance Ru(II) complex

SCI ; EI

英语

通讯

Guangdong Basic and Applied Basic Research Foundation["2021B1515020050","2023B1515020060"] ; Science and Technology Foundation of Shenzhen["JCYJ20210324095200002","JCYJ20220531103405012","RCYX20221008092906021"] ; Fundamental Research Funds for the Central Universities[22lgqb37] ; null[NSFC 22277153] ; null[22007104] ; null[21931002] ; null[22077085]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:001209028900001

WILEY

Web of Science

1.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen Campus, Shenzhen 510275, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China
4.Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China
5.Wenzhou Med Univ, Inst Adv Res, Cixi Biomed Res Inst, Wenzhou, Peoples R China
6.Guangdong Univ Technol, Light Ind & Chem Engn Coll, Guangzhou 510006, Peoples R China
7.Sun Yat Sen Univ, Affiliated Hosp 7, Dept Oncol, Shenzhen 518107, Peoples R China

Dao, Anyi,Chen, Shiyan,Pan, Li,et al. A 700 nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis[J]. ADVANCED HEALTHCARE MATERIALS,2024.

Dao, Anyi.,Chen, Shiyan.,Pan, Li.,Ren, Qingyan.,Wang, Xun.,...&Huang, Huaiyi.(2024).A 700 nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis.ADVANCED HEALTHCARE MATERIALS.

Dao, Anyi,et al."A 700 nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis".ADVANCED HEALTHCARE MATERIALS (2024).