An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes

Wang, Yajun1,2,3; Zhou, Ding4; Ma, Huilong5; Liu, Dahai1; Liang, Yongye5; Zhu, Shoujun2,3,6

2024-04-01

10.1007/s00259-024-06702-0

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   影响因子和分区

1619-7070

1619-7089

Purpose The accuracy of surgery for patients with solid tumors can be greatly improved through fluorescence-guided surgery (FGS). However, existing FGS technologies have limitations due to their low penetration depth and sensitivity/selectivity, which are particularly prevalent in the relatively short imaging window (< 900 nm). A solution to these issues is near-infrared-II (NIR-II) FGS, which benefits from low autofluorescence and scattering under the long imaging window (> 900 nm). However, the inherent self-assembly of organic dyes has led to high accumulation in main organs, resulting in significant background signals and potential long-term toxicity. Methods We rationalize the donor structure of donor-acceptor-donor-based dyes to control the self-assembly process to form an ultra-small dye nanocluster, thus facilitating renal excretion and minimizing background signals. Results Our dye nanocluster can not only show clear vessel imaging, tumor and tumor sentinel lymph nodes definition, but also achieve high-performance NIR-II imaging-guided surgery of tumor-positive sentinel lymph nodes. Conclusion In summary, our study demonstrates that the dye nanocluster-based NIR-II FGS has substantially improved outcomes for radical lymphadenectomy.

NIR-II dyes Dye nanocluster NIR-II emission Renal excretion NIR-II imaging-guided surgery

SCI ; EI

英语

通讯

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:001197982800001

SPRINGER

CLINICAL MEDICINE

Web of Science

1.Jilin Univ, China Japan Union Hosp, Dept Vasc Surg, Changchun 130033, Peoples R China
2.Jilin Univ, Coll Chem, Ctr Supramol Chem Biol, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
3.First Hosp Jilin Univ, Joint Lab Optofunct Theranost Med & Chem, Changchun 130021, Peoples R China
4.Jilin Univ, Sch & Hosp Stomatol, Jilin Prov Key Lab Tooth Dev & Bone Remodeling, Changchun 130021, Peoples R China
5.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
6.First Hosp Jilin Univ, Inst Immunol, Key Lab Organ Regenerat & Transplantat, Minist Educ, Changchun 130021, Peoples R China

Wang, Yajun,Zhou, Ding,Ma, Huilong,et al. An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2024.

Wang, Yajun,Zhou, Ding,Ma, Huilong,Liu, Dahai,Liang, Yongye,&Zhu, Shoujun.(2024).An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING.

Wang, Yajun,et al."An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2024).