南方科技大学知识苑(SUSTech KC): Inverse relationship between HBV DNA levels and liver histopathological changes in immune-tolerant CHB patients

题名	Inverse relationship between HBV DNA levels and liver histopathological changes in immune-tolerant CHB patients
作者	Huang, Deliang 1; Lai, Huiyi 1; Zhu, Zhibin 1; Yu, Hong 2; Peng, Jinghan 1; Chen, Yuanyuan 1; Liao, Xuejiao 1; Chen, Jun1
通讯作者	Chen, Jun
发表日期	2024-07-01
DOI	10.1111/jvh.13940
发表期刊	JOURNAL OF VIRAL HEPATITIS 影响因子和分区
ISSN	1352-0504
EISSN	1365-2893
卷号	31 期号:7
摘要	Limited data exist regarding the association between hepatitis B virus (HBV) DNA levels and liver histopathological changes in patients with chronic hepatitis B (CHB) during the immune tolerant (IT) phase. In this study, we retrospectively analysed liver biopsy results from 150 adult IT-CHB patients. The liver tissue necroinflammation and fibrosis were evaluated by the Scheuer scoring system. Multivariate logistic regression, smooth curve fitting, and segmented regression models were used to examine the association between HBV DNA levels and liver histopathological changes. A total of 26%, 30.67% and 42% of IT patients had significant necroinflammation (>= G2), significant fibrosis (>= S2) and significant histopathological changes (>= G2 and/or >= S2), respectively. HBV DNA levels were independently and non-linear inversely associated with significant necroinflammation and histopathological changes in IT-CHB patients. Patients with HBV DNA levels <10(7) IU/mL had a higher risk of significant histopathological changes compared to those with levels >10(7) IU/mL. The findings were further confirmed by smooth curve fitting analyses, subgroup and sensitivity analyses. In segmented regression model analyses, the optimal DNA value for the lowest odds ratio of significant histopathological changes was 7.26 log10 IU/mL. A non-linear inverse association between HBV DNA levels and significant histopathological changes in IT-CHB patients. DNA 7.26 log10 IU/mL may serve as a potential cut-off point to define a 'true immune tolerant phase' with minimal liver histopathological changes.
关键词	chronic hepatitis B HBV DNA immune tolerant phase liver biopsy
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
WOS研究方向	Gastroenterology & Hepatology ; Infectious Diseases ; Virology
WOS类目	Gastroenterology & Hepatology ; Infectious Diseases ; Virology
WOS记录号	WOS:001197612400001
出版者	WILEY
ESI学科分类	IMMUNOLOGY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788679
专题	南方科技大学第二附属医院
作者单位	1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Dept Liver Dis, Affiliated Hosp 2, Shenzhen 518100, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Affiliated Hosp 2, Dept Pathol, Shenzhen, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院
通讯作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Huang, Deliang,Lai, Huiyi,Zhu, Zhibin,et al. Inverse relationship between HBV DNA levels and liver histopathological changes in immune-tolerant CHB patients[J]. JOURNAL OF VIRAL HEPATITIS,2024,31(7).
APA	Huang, Deliang.,Lai, Huiyi.,Zhu, Zhibin.,Yu, Hong.,Peng, Jinghan.,...&Chen, Jun.(2024).Inverse relationship between HBV DNA levels and liver histopathological changes in immune-tolerant CHB patients.JOURNAL OF VIRAL HEPATITIS,31(7).
MLA	Huang, Deliang,et al."Inverse relationship between HBV DNA levels and liver histopathological changes in immune-tolerant CHB patients".JOURNAL OF VIRAL HEPATITIS 31.7(2024).