Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study

Liu, Kai1; Ma, Xin-Yi2; Xiao, Hua3; Gu, Wan-Jie1; Lyu, Jun4; Yin, Hai-Yan1

2024-03-29

10.1186/s12931-024-02771-9

RESPIRATORY RESEARCH   影响因子和分区

1465-993X

Background: Although ROX index is frequently used to assess the efficacy of high-flow nasal cannula treatment in acute hypoxemic respiratory failure (AHRF) patients, the relationship between the ROX index and the mortality remains unclear. Therefore, a retrospective cohort study was conducted to evaluate the ability of the ROX index to predict mortality risk in patients with AHRF. Method: Patients diagnosed with AHRF were extracted from the MIMIC-IV database and divided into four groups based on the ROX index quartiles. The primary outcome was 28-day mortality, while in-hospital mortality and follow-up mortality were secondary outcomes. To investigate the association between ROX index and mortality in AHRF patients, restricted cubic spline curve and COX proportional risk regression were utilized. Result: A non-linear association (L-shaped) has been observed between the ROX index and mortality rate. When the ROX index is below 8.28, there is a notable decline in the 28-day mortality risk of patients as the ROX index increases (HR per SD, 0.858 [95%CI 0.794-0.928] P < 0.001). When the ROX index is above 8.28, no significant association was found between the ROX index and 28-day mortality. In contrast to the Q1 group, the mortality rates in the Q2, Q3, and Q4 groups had a substantial reduction (Q1 vs. Q2: HR, 0.749 [0.590-0.950] P = 0.017; Q3: HR, 0.711 [0.558-0.906] P = 0.006; Q4: HR, 0.641 [0.495-0.830] P < 0.001). Conclusion: The ROX index serves as a valuable predictor of mortality risk in adult patients with AHRF, and that a lower ROX index is substantially associated with an increase in mortality.

ROX index Acute hypoxemic respiratory failure Mortality MIMIC-IV

SCI

英语

其他

Respiratory System

Respiratory System

WOS:001195354900001

BMC

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Affiliated Hosp 1, Dept Intens Care Unit, 613 Huangpu Ave West, Guangzhou 510630, Peoples R China
2.Southern Med Univ, Clin Med Coll 1, Guangzhou, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1, Dept Nephrol,Clin Med Coll 2, Shenzhen, Peoples R China
4.Jinan Univ, Affiliated Hosp 1, Dept Clin Res, Guangzhou, Guangdong, Peoples R China

Liu, Kai,Ma, Xin-Yi,Xiao, Hua,et al. Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study[J]. RESPIRATORY RESEARCH,2024,25(1).

Liu, Kai,Ma, Xin-Yi,Xiao, Hua,Gu, Wan-Jie,Lyu, Jun,&Yin, Hai-Yan.(2024).Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study.RESPIRATORY RESEARCH,25(1).

Liu, Kai,et al."Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study".RESPIRATORY RESEARCH 25.1(2024).