Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model

Lu, Beibei1,2,3,4,5; Zhong, Yixiu1,2,3; Zhang, Jianglin1,2,3; Zhang, Jiaheng4,5

2024-04-01

10.1021/acsami.3c17091

ACS APPLIED MATERIALS & INTERFACES   影响因子和分区

1944-8244

1944-8252

Psoriasis is a systemic, recurrent, chronic autoimmune skin disease. However, psoriasis drugs have poor skin permeability and high toxicity, resulting in low bioavailability and affecting their clinical application. In this study, we propose a curcumin-based ionic liquid hydrogel loaded with ilomastat (Cur-Car-IL@Ilo hydrogel), which can effectively maintain the sustained release of drugs and improve the skin permeability of drugs. We used a model of imiquimod-induced psoriasis and demonstrated that local application of Cur-Car-IL@Ilo hydrogel can improve skin lesions in mice with significantly reduced expression levels of inflammatory factors, matrix metalloproteinase 8, and collagen-I. The expressions of iron death-related proteins SLC7A11 and ASL4 were significantly decreased after treatment with Cur-Car-IL@Ilo hydrogel. Flora analysis showed that the content of anaerotruncus, proteus, and UCG-009 bacteria in the gut of psoriatic mice increased. The levels of paludicola, parabacteroides, prevotellaceae_UCG-001, escherichia-shigella, and aerococcus decreased, and the levels of some of the above bacteria tended to be normal after treatment. Therefore, the curcumin-based ionic liquid hydrogel can be used as a multifunctional, nonirritating, noninvasive, and highly effective percutaneous treatment of psoriasis.

curcumin ionic liquid hydrogel transdermal delivery psoriasis

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China["82073018","21905069"] ; National Natural Science Foundation of China["ZDSYS20190902093220279","KQTD20170809110344233"] ; Shenzhen Science and Technology Innovation Committee[2020A1515110879] ; Department of Science and Technology of Guangdong Province[2023M732379]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001195037700001

AMER CHEMICAL SOC

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Dept Dermatol, Clin Med Coll 2,Affiliated Hosp 1,Shenzhen Peoples, Shenzhen 518020, Guangdong, Peoples R China
2.Natl Clin Res, Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China
3.Peoples Hosp Geriatr Ctr, Dept Shenzhen, Shenzhen 518020, Guangdong, Peoples R China
4.Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
5.Harbin Inst Technol Shenzhen, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China

Lu, Beibei,Zhong, Yixiu,Zhang, Jianglin,et al. Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model[J]. ACS APPLIED MATERIALS & INTERFACES,2024,16(14).

Lu, Beibei,Zhong, Yixiu,Zhang, Jianglin,&Zhang, Jiaheng.(2024).Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model.ACS APPLIED MATERIALS & INTERFACES,16(14).

Lu, Beibei,et al."Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model".ACS APPLIED MATERIALS & INTERFACES 16.14(2024).