南方科技大学知识苑(SUSTech KC): Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer

题名	Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer
作者	Zhong, Xiaoling 1; Zeng, Guohua 1; Zhang, Lixiang 1; You, Shuyuan 2; Fu, Yuxiang 3; He, Wan 4; Liao, Guixiang 5
通讯作者	Liao, Guixiang
发表日期	2024-03-11
DOI	10.3389/fonc.2024.1361300
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
ISSN	2234-943X
卷号	14
摘要	Purpose To investigate the predictive factors of pathologic complete response (pCR) in locally advanced rectal cancer (LARC) patients who had been treated with neoadjuvant chemoradiation (nCRT).Methods and materials For this retrospective study, 53 LARC patients (37 males and 16 females; age range 25 to 79 years) were selected. Clinical characteristics, baseline mrTNM staging, MR gross tumor volumes (GTV), and pCR were evaluated. The diagnostic accuracy of GTV for predicting pCR was calculated.Results Among 53 LARC patients, 15 patients achieved pCR (28.3%), while 38 patients achieved non-pCR. Only three (5.7%) out of 53 patients did not downstage after nCRT. GTV and tumor differentiation were the significant prognostic parameters for predicting pCR. A tumor volume threshold of 21.1 cm3 was determined as a predictor for pCR, with a sensitivity of 84% and specificity of 47%. In addition, GTV was associated with mrN stage, circumferential resection margin (CRM) status, extramural vascular invasion (EMVI) status, and pretreatment serum CEA level.Conclusion Tumor volume and tumor differentiation have significant predictive values in preoperative assessment of pCR among LARC patients. These findings aid clinicians to discriminate those patients who may likely benefit from preoperative regimens and to make optimal treatment plans.
关键词	LARC NCRT PCR MRI tumor volume tumor differentiation
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Science of Shenzhen[JCYJ20220530152001002]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:001189897500001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788785
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Radiol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China 2.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Pathol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen, Peoples R China 3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Gastrointestinal Surg,Affiliated Hosp 1,Clin, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Oncol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen, Peoples R China 5.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Radiat Oncol,Affiliated Hosp 1,Clin Med Coll, Shenzhen, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Zhong, Xiaoling,Zeng, Guohua,Zhang, Lixiang,et al. Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer[J]. FRONTIERS IN ONCOLOGY,2024,14.
APA	Zhong, Xiaoling.,Zeng, Guohua.,Zhang, Lixiang.,You, Shuyuan.,Fu, Yuxiang.,...&Liao, Guixiang.(2024).Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer.FRONTIERS IN ONCOLOGY,14.
MLA	Zhong, Xiaoling,et al."Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer".FRONTIERS IN ONCOLOGY 14(2024).