Ultrastable Iodinated Oil-Based Pickering Emulsion Enables Locoregional Sustained Codelivery of Hypoxia Inducible Factor-1 Inhibitor and Anticancer Drugs for Tumor Combination Chemotherapy

Li, Zhihua1; Liu, Xiaoya1; Xiao, Jingyu1; Jiang, Hang2; Ma, Le1; Luo, Yucheng1; Wang, Meijuan1; Zhu, Yuwei3; Jiang, Hongliang1; Yao, Hanyang1; Ngai, To3; Guo, Qiongyu1

2024-03-27

10.1021/acsbiomaterials.3c01887

ACS BIOMATERIALS SCIENCE & ENGINEERING   影响因子和分区

2373-9878

Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i.e., acriflavine and doxorubicin). We found that the codelivery of acriflavine and doxorubicin from the PE promoted the local accumulation and retention of both drugs using an acellular liver organ model and demonstrated significant inhibition of tumor growth in a 4T1 tumor-bearing mouse model, improving the chemotherapeutic efficacy through the synergistic effects of direct cytotoxicity with the functional suppression of HIF-1 pathways of tumor cells. Such an iodinated oil-based PE provides a great injectable sustained delivery platform of hydrophilic drugs for locoregional chemotherapy.

hypoxia iodinated oil Pickering emulsion drug delivery locoregional chemotherapy

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[2019ZT08Y191] ; Guangdong Research Fund[JCYJ20200109141638004] ; Innovation Committee of Shenzhen Municipality[2022B1212010003] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[ZDSYS20200811144003009]

Materials Science

Materials Science, Biomaterials

WOS:001192923600001

AMER CHEMICAL SOC

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
2.Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Synthet & Biol Colloids, Minist Educ, Wuxi 214122, Peoples R China
3.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong 999077, Peoples R China

Li, Zhihua,Liu, Xiaoya,Xiao, Jingyu,et al. Ultrastable Iodinated Oil-Based Pickering Emulsion Enables Locoregional Sustained Codelivery of Hypoxia Inducible Factor-1 Inhibitor and Anticancer Drugs for Tumor Combination Chemotherapy[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2024,10(4).

Li, Zhihua.,Liu, Xiaoya.,Xiao, Jingyu.,Jiang, Hang.,Ma, Le.,...&Guo, Qiongyu.(2024).Ultrastable Iodinated Oil-Based Pickering Emulsion Enables Locoregional Sustained Codelivery of Hypoxia Inducible Factor-1 Inhibitor and Anticancer Drugs for Tumor Combination Chemotherapy.ACS BIOMATERIALS SCIENCE & ENGINEERING,10(4).

Li, Zhihua,et al."Ultrastable Iodinated Oil-Based Pickering Emulsion Enables Locoregional Sustained Codelivery of Hypoxia Inducible Factor-1 Inhibitor and Anticancer Drugs for Tumor Combination Chemotherapy".ACS BIOMATERIALS SCIENCE & ENGINEERING 10.4(2024).