南方科技大学知识苑(SUSTech KC): Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6-and caspase-3-mediated mitochondrial apoptosis

题名	Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6-and caspase-3-mediated mitochondrial apoptosis
作者	Guo, Qiuyan 1,2; Zhao, Minghong 4,5; Wang, Qixin 1,2; Lu, Tianming 1,2; Luo, Piao 1,2; Chen, Lin 1,2; Xia, Fei 1,2; Pang, Huanhuan 1,2; Shen, Shengnan 1,2; Cheng, Guangqing 1,2; Dai, Chuanhao 1,2; Meng, Yuqing 1,2; Zhong, Tianyu 4,5; Qiu, Chong 1,2; Wang, Jigang 1,2,3
通讯作者	Zhong, Tianyu; Qiu, Chong; Wang, Jigang
发表日期	2024-04-01
DOI	10.1016/j.biopha.2024.116304
发表期刊	BIOMEDICINE & PHARMACOTHERAPY 影响因子和分区
ISSN	0753-3322
EISSN	1950-6007
卷号	173
摘要	Glycyrrhetinic acid (GA) shows great efficiency against non-small cell lung cancer (NSCLC), but the detailed mechanism is unclear, which has limited its clinical application. Herein, we investigated the potential targets of GA against NSCLC by activity-based protein profiling (ABPP) technology and the combination of histopathology and proteomics validation. In vitro and in vivo results indicated GA significantly inhibited NSCLC via promotion of peroxiredoxin-6 (Prdx6) and caspase-3 (Casp3)-mediated mitochondrial apoptosis. This original finding will provide theoretical and data support to improve the treatment of NSCLC with the application of GA.
关键词	Glycyrrhetinic acid NSCLC Activity-based protein profiling
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Fundamental Research Funds for the Central Public Welfare Research Institutes[2021QNRC2B29] ; Shenzhen Medical Research Fund["ZXKT19018","ZZ14-YQ-055","ZXKT19021","ZZ14-YQ-059","ZXKT19022","ZZ14-YQ-060","ZZ16-ND-10-05","ZZ16-ND-10-17 ZZ17-ND-10-05"] ; null[B2302051]
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号	WOS:001192302000001
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
来源库	Web of Science
引用统计	被引频次[WOS]：5
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788829
专题	南方科技大学第一附属医院
作者单位	1.China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 3.Shenzhen Peoples Hosp, Shenzhen Inst Resp Dis, Shenzhen Clin Res Ctr Geriatr, Dept Pulm & Crit Care Med, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China 5.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Guo, Qiuyan,Zhao, Minghong,Wang, Qixin,et al. Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6-and caspase-3-mediated mitochondrial apoptosis[J]. BIOMEDICINE & PHARMACOTHERAPY,2024,173.
APA	Guo, Qiuyan.,Zhao, Minghong.,Wang, Qixin.,Lu, Tianming.,Luo, Piao.,...&Wang, Jigang.(2024).Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6-and caspase-3-mediated mitochondrial apoptosis.BIOMEDICINE & PHARMACOTHERAPY,173.
MLA	Guo, Qiuyan,et al."Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6-and caspase-3-mediated mitochondrial apoptosis".BIOMEDICINE & PHARMACOTHERAPY 173(2024).