Role of remnant cholesterol in the relationship between physical activity and diabetes mellitus: an intermediary analysis

Yang, Zihua1; Chen, Hao1; Lai, Fengxia1; Zhang, Jingjing1; Wang, Shihong1; Wang, Shuang1; Chen, Yongze1,2; Mai, Zhenhua1,2; Luo, Ling3; Kong, Danli1; Ding, Yuanlin1

2024-03-12

10.3389/fpubh.2024.1322244

FRONTIERS IN PUBLIC HEALTH   影响因子和分区

2296-2565

Objective: The purpose of this investigation was to evaluate the potential link between physical activity (PA) and the heightened susceptibility to diabetes mellitus (DM), by examining whether remnant cholesterol (RC) might act as a mediator in this correlation. Methods: The research utilized data from the National Health and Nutrition Examination Survey, spanning from 2005 to 2018. Various statistical analyses were conducted for continuous and categorical variables, including the t-test, ANOVA, and (sic)(2) test. Logistic regression was employed to analyze the association between PA and DM across three distinct models. Mediation analysis was also conducted to assess the potential mediation effects of RC. Results: The study encompassed a total of 9,149 participants, and it was observed that individuals with DM exhibited lower levels of PA. Furthermore, PA levels were found to be associated with all participant characteristics except poverty income ratio, fasting blood glucose, and HOMA-IR (p < 0.05). After adjusting for covariates (Model 3), individuals with high PA levels demonstrated a decreased likelihood of developing DM compared to those in the low PA group (OR: 0.73, 95%CI: 0.54-0.99). A significant dose-response relationship was identified (p < 0.05). No interaction between PA and RC in relation to DM risk was detected, and RC was found to serve as a mediator in the connection between PA and DM. After considering covariates, the mediating effect of RC between PA and DM weakens. Discussion: Our findings suggest that higher levels of PA are linked to a reduced risk of DM in U.S. adults, with RC likely playing a mediating role.

diabetes mellitus physical activity remnant cholesterol intermediary analysis National Health and Nutrition Examination Survey

SCI ; SSCI

英语

通讯

Discipline Construction Project of Guangdong Medical University["4SG21276P","1003K20220004"] ; Guangdong Province Foundation and Applied Basic Re-search Foundation Regional Joint Fund[2020B1515120021] ; Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund[2022A1515220196] ; Guangdong Province General University Characteristic Innovation Project["2020KTSCX042","2019KTSCX046"] ; Undergraduate Teaching Quality and Teaching Reform Project[1JG22125]

Public, Environmental & Occupational Health

Public, Environmental & Occupational Health

WOS:001190368100001

FRONTIERS MEDIA SA

Web of Science

1.Guangdong Med Univ, Sch Publ Hlth, Dept Epidemiol & Med Stat, Dongguan, Guangdong, Peoples R China
2.Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China
3.South Univ Sci & Technol China, Sch Publ Hlth & Emergency Management, Shenzhen, Guangdong, Peoples R China

Yang, Zihua,Chen, Hao,Lai, Fengxia,et al. Role of remnant cholesterol in the relationship between physical activity and diabetes mellitus: an intermediary analysis[J]. FRONTIERS IN PUBLIC HEALTH,2024,12.

Yang, Zihua.,Chen, Hao.,Lai, Fengxia.,Zhang, Jingjing.,Wang, Shihong.,...&Ding, Yuanlin.(2024).Role of remnant cholesterol in the relationship between physical activity and diabetes mellitus: an intermediary analysis.FRONTIERS IN PUBLIC HEALTH,12.

Yang, Zihua,et al."Role of remnant cholesterol in the relationship between physical activity and diabetes mellitus: an intermediary analysis".FRONTIERS IN PUBLIC HEALTH 12(2024).