Iridium(iii) complexes decorated with silicane-modified rhodamine: near-infrared light-initiated photosensitizers for efficient deep-tissue penetration photodynamic therapy

Liu, Jiqiang1,2,3; Yang, Xing2; Wu, Siye1; Gong, Ping2; Pan, Fan2; Zhang, Pengfei2; Lee, Chi-Sing3; Liu, Chuangjun4; Wong, Keith Man-Chung1

2024-04-17

10.1039/d4tb00075g

JOURNAL OF MATERIALS CHEMISTRY B   影响因子和分区

2050-750X

2050-7518

Meeting the demand for efficient photosensitizers in photodynamic therapy (PDT), a series of iridium(iii) complexes decorated with silicane-modified rhodamine (Si-rhodamine) was meticulously designed and synthesized. These complexes demonstrate exceptional PDT potential owing to their strong absorption in the near-infrared (NIR) spectrum, particularly responsive to 808 nm laser stimulation. This feature is pivotal, enabling deep-penetration laser excitation and overcoming depth-related challenges in clinical PDT applications. The molecular structures of these complexes allow for reliable tuning of singlet oxygen generation with NIR excitation, through modification of the cyclometalating ligand. Notably, one of the complexes (4) exhibits a remarkable ROS quantum yield of 0.69. In vivo results underscore the efficacy of 4, showcasing significant tumor regression at depths of up to 8.4 mm. This study introduces a promising paradigm for designing photosensitizers capable of harnessing NIR light effectively for deep PDT applications.

SCI ; EI

英语

第一 ; 通讯

China Postdoctoral Science Foundation[21771099] ; National Natural Science Foundation of China[2016A030312006] ; Guangdong Natural Science Foundation of Research Team["JCYJ20160429191503002","JCYJ20170818162522440","JCYJ20170818154843625"] ; Shenzhen Science and Technology Program["JCYJ20170817110721105","JCYJ20190809165411528"] ; Science, Technology and Innovation Commission of Shenzhen Municipality[2019M660219] ; China Postdoctoral Science Foundation[Y959101001] ; Special Research Assistant Project of the Chinese Academy of Sciences[2019A1515110222]

Materials Science

Materials Science, Biomaterials

WOS:001190787500001

ROYAL SOC CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Chem, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Key Lab Nanomed, Shenzhen Engn Lab Nanomed & Nanoformulat,Key Lab I, Shenzhen 518055, Peoples R China
3.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
4.Huanghuai Univ, Coll Chem & Pharmaceut Engn, Zhumadian 463000, Peoples R China

Liu, Jiqiang,Yang, Xing,Wu, Siye,et al. Iridium(iii) complexes decorated with silicane-modified rhodamine: near-infrared light-initiated photosensitizers for efficient deep-tissue penetration photodynamic therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2024,12(15).

Liu, Jiqiang.,Yang, Xing.,Wu, Siye.,Gong, Ping.,Pan, Fan.,...&Wong, Keith Man-Chung.(2024).Iridium(iii) complexes decorated with silicane-modified rhodamine: near-infrared light-initiated photosensitizers for efficient deep-tissue penetration photodynamic therapy.JOURNAL OF MATERIALS CHEMISTRY B,12(15).

Liu, Jiqiang,et al."Iridium(iii) complexes decorated with silicane-modified rhodamine: near-infrared light-initiated photosensitizers for efficient deep-tissue penetration photodynamic therapy".JOURNAL OF MATERIALS CHEMISTRY B 12.15(2024).