Naturally Derived Injectable Dual-Cross-Linked Adhesive Hydrogel for Acute Hemorrhage Control and Wound Healing

Zhu, Ziran1,2,3; Ye, Huijun2; Zhang, Kaiwen2; He, Gang2; Pan, Zheng2; Xian, Yiwen2; Yang, Yu2; Zhang, Chong2; Wu, Decheng2

2024-03-25

10.1021/acs.biomac.4c00105

BIOMACROMOLECULES   影响因子和分区

1525-7797

1526-4602

Developing biocompatible injectable hydrogels with high mechanical strength and rapid strong tissue adhesion for hemostatic sealing of uncontrolled bleeding remains a prevailing challenge. Herein, we engineer an injectable and photo-cross-linkable hydrogel based on naturally derived gelatin methacrylate (GelMA) and N-hydroxysuccinimide-modified poly(gamma-glutamic acid) (gamma PGA-NHS). The chemically dual-cross-linked hydrogel rapidly forms after UV light irradiation and covalently bonds to the underlying tissue to provide robust adhesion. We demonstrate a significantly improved hemostatic efficacy of the hydrogel using various injury models in rats compared to the commercially available fibrin glue. Notably, the hydrogel can achieve hemostasis in porcine liver and spleen incision, and femoral artery puncture models. Moreover, the hydrogel is used for sutureless repair of the liver defect in a rat model with a significantly suppressed inflammatory response, enhanced angiogenesis, and superior healing efficacy compared to fibrin glue. Together, this study offers a promising bioadhesive for treating severe bleeding and facilitating wound repair.

SCI ; EI

英语

通讯

National Natural Science Foundation of China[2020YFA0908900] ; Ministry of Science and Technology of China["21935011","21725403"] ; National Natural Science Foundation of China["KQTD20200820113012029","JCYJ20220818100601003"] ; Shenzhen Science and Technology Innovation Commission[2022A1515110321] ; Guangdong Basic and Applied Basic Research Foundation[2022B1212010003]

Biochemistry & Molecular Biology ; Chemistry ; Polymer Science

Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science

WOS:001190683200001

AMER CHEMICAL SOC

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Zhu, Ziran,Ye, Huijun,Zhang, Kaiwen,et al. Naturally Derived Injectable Dual-Cross-Linked Adhesive Hydrogel for Acute Hemorrhage Control and Wound Healing[J]. BIOMACROMOLECULES,2024,25(4).

Zhu, Ziran.,Ye, Huijun.,Zhang, Kaiwen.,He, Gang.,Pan, Zheng.,...&Wu, Decheng.(2024).Naturally Derived Injectable Dual-Cross-Linked Adhesive Hydrogel for Acute Hemorrhage Control and Wound Healing.BIOMACROMOLECULES,25(4).

Zhu, Ziran,et al."Naturally Derived Injectable Dual-Cross-Linked Adhesive Hydrogel for Acute Hemorrhage Control and Wound Healing".BIOMACROMOLECULES 25.4(2024).