Prophylactic antibiotics for preventing ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis

Zha, Shanshan1,2; Niu, Jianyi1,2; He, Zhenfeng1,2; Fu, Wei1,2; Huang, Qiaoyun1,2; Guan, Lili1,2; Zhou, Luqian1,2; Chen, Rongchang1,2,3

2023-09-15

10.1186/s40001-023-01323-z

EUROPEAN JOURNAL OF MEDICAL RESEARCH   影响因子和分区

0949-2321

2047-783X

["Background The role of prophylactic antibiotics in preventing ventilator-associated pneumonia (VAP) in patients undergoing invasive mechanical ventilation (IMV) remains unclear. This network meta-analysis compared the efficacy and safety of antibiotic prophylaxis in preventing VAP in an IMV population in intensive-care units (ICUs).","Methods We searched the PubMed, Web of Science, Embase, and Cochrane Library databases from inception to December 2021, to identify relevant studies assessing the impact of prophylactic antibiotics on the incidence of VAP, the mortality, and the duration of ICU stays and hospitalization to perform a meta-analysis.","Results Thirteen studies (2144 patients) were included, 12 of which were selected for the primary analysis, which revealed that treatment with prophylactic antibiotics resulted in a lower VAP rate compared with control groups [risk ratio (RR) = 0.62]. Bayesian network meta-analysis indicated that aerosolized tobramycin and intravenous ampicillin-sulbactam presented the greatest likelihood being the most efficient regimen for reducing VAP.","Conclusions Antibiotic prophylaxis may reduce the incidence of VAP, but not the mortality, for adult patients undergoing IMV in ICUs. Tobramycin via nebulization and ampicillin-sulbactam via intravenous administration presented the greatest likelihood of being the most efficient regimen for preventing VAP. However, well- designed randomized studies are warranted before definite recommendations can be made."]

Prophylactic antibiotics Ventilator-associated pneumonia Network meta-analysis

SCI

英语

通讯

National Natural Science Foundation of China[82200046] ; State Key Laboratory of Respiratory Disease[SKLRD-Z-202203] ; Guangdong Basic and Applied Basic Research Foundation[2022A1515110233] ; Tertiary Education Scientific research project of Guangzhou Municipal Education Bureau[202235392] ; Guangzhou Health Science and Technology Project of Guangzhou Municipal Health Commission[20231A011079] ; Basic and Applied Basic Research Project of Guangzhou Municipal Science and Technology Bureau[2023A04J0571]

Research & Experimental Medicine

Medicine, Research & Experimental

WOS:001188591800001

BMC

CLINICAL MEDICINE

Web of Science

1.Guangzhou Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Resp Dis,Natl Ctr Resp Med, State Key Lab Resp Dis,Guangzhou Inst Resp Hlth, 151 Yanjiang Rd, Guangzhou 510120, Guangdong, Peoples R China
2.Guangzhou Med Univ, Affiliated Hosp 1, Natl Ctr Resp Med, Resp Mech Lab,Guangzhou Inst Resp Hlth, Guangzhou, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ,Clin Med Coll 2,Shenzhen Peoples Hosp, Dept Resp & Crit Care Med,Shenzhen Inst Resp Dis, Shenzhen 518020, Guangdong, Peoples R China

Zha, Shanshan,Niu, Jianyi,He, Zhenfeng,et al. Prophylactic antibiotics for preventing ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis[J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH,2023,28(1).

Zha, Shanshan.,Niu, Jianyi.,He, Zhenfeng.,Fu, Wei.,Huang, Qiaoyun.,...&Chen, Rongchang.(2023).Prophylactic antibiotics for preventing ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis.EUROPEAN JOURNAL OF MEDICAL RESEARCH,28(1).

Zha, Shanshan,et al."Prophylactic antibiotics for preventing ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis".EUROPEAN JOURNAL OF MEDICAL RESEARCH 28.1(2023).