Nonalcoholic Fatty Liver Disease: Changes in Gut Microbiota and Blood Lipids

Yang, Keen; Zeng, Jieying; Wu, Huaiyu; Liu, Huiyu; Ding, Zhimin; Liang, Weiyu; Wu, Linghu; Lin, Ziwei; Huang, Wenhui; Xu, Jinfeng; Dong, Fajin

2024-04-01

10.14218/JCTH.2023.00199

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY   影响因子和分区

2225-0719

2310-8819

Background and Aims: The global prevalence of nonalcoholic fatty liver disease (NAFLD) is 25%. This study explored differences in the gut microbial community and blood lipids between normal livers and those affected by NAFLD using 16S ribosomal deoxyribonucleic acid sequencing. Methods: Gut microbiome profiles of 40 NAFLD and 20 non-NAFLD controls were analyzed. Information about four blood lipids and 13 other clinical features was collected. Patients were divided into three groups by ultrasound and FibroScan, those with a normal liver, mild FL (FL1), and moderate -to -severe FL (FL2). FL1 and FL2 patients were divided into two groups, those with either hyperlipidemia or non-hyperlipidemia based on their blood lipids. Potential keystone species within the groups were identified using univariate analysis and a speci ficity-occupancy plot. Significant difference in biochemical parameters ion NAFLD patients and healthy individuals were identified by detrended correspondence analysis and canonical correspondence analysis. Results: Decreased gut bacterial diversity was found in patients with NAFLD. Firmicutes/ Bacteroidetes decreased as NAFLD progressed. Faecalibacterium and Ruminococcus 2 were the most representative fatty -related bacteria. Glutamate pyruvic transaminase, aspartate aminotransferase, and white blood cell count were selected as the most significant biochemical indexes. Calculation of areas under the curve identified two microbiomes combined with the three biochemical indexes that identified normal liver and FL2 very well but performed poorly in diagnosing FL1. Conclusions: Faecalibacterium and Ruminococcus 2, combined with glutamate pyruvic transaminase, - aspartate aminotransferase, and white blood cell count distinguished NAFLD. We speculate that regulating the health of gut microbiota may release NAFLD, in addition to providing new targets for clinicians to treat NAFLD.

Liver Gut microbiota Blood lipids Nonalcoholic fatty liver disease Hyperlipidemia

SCI

英语

其他

Commission of Science and Technology of Shenzhen[GJHZ20200731095401004] ; Medjaden Academy & Research Foundation for Young Scientists[MJA202306057]

Gastroenterology & Hepatology

Gastroenterology & Hepatology

WOS:001188127800001

XIA & HE PUBLISHING INC

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Dept Ultrasound, Clin Med Coll 2, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China

Yang, Keen,Zeng, Jieying,Wu, Huaiyu,et al. Nonalcoholic Fatty Liver Disease: Changes in Gut Microbiota and Blood Lipids[J]. JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY,2024,12(4).

Yang, Keen.,Zeng, Jieying.,Wu, Huaiyu.,Liu, Huiyu.,Ding, Zhimin.,...&Dong, Fajin.(2024).Nonalcoholic Fatty Liver Disease: Changes in Gut Microbiota and Blood Lipids.JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY,12(4).

Yang, Keen,et al."Nonalcoholic Fatty Liver Disease: Changes in Gut Microbiota and Blood Lipids".JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY 12.4(2024).