Novel insights into small open reading frame-encoded micropeptides in hepatocellular carcinoma: A potential breakthrough

Zhang, Qiangnu; Liu, Liping

2024-04-10

10.1016/j.canlet.2024.216691

CANCER LETTERS   影响因子和分区

0304-3835

1872-7980

Traditionally, non -coding RNAs (ncRNAs) are regarded as a class of RNA transcripts that lack encoding capability; however, advancements in technology have revealed that some ncRNAs contain small open reading frames (sORFs) that are capable of encoding micropeptides of approximately 150 amino acids in length. sORF-encoded micropeptides (SEPs) have emerged as intriguing entities in hepatocellular carcinoma (HCC) research, shedding light on this previously unexplored realm. Recent studies have highlighted the regulatory functions of SEPs in the occurrence and progression of HCC. Some SEPs exhibit inhibitory effects on HCC, but others facilitate its development. This discovery has revolutionized the landscape of HCC research and clinical management. Here, we introduce the concept and characteristics of SEPs, summarize their associations with HCC, and elucidate their carcinogenic mechanisms in HCC metabolism, signaling pathways, cell proliferation, and metastasis. In addition, we propose a step-by-step workflow for the investigation of HCC-associated SEPs. Lastly, we discuss the challenges and prospects of applying SEPs in the diagnosis and treatment of HCC. This review aims to facilitate the discovery, optimization, and clinical application of HCC-related SEPs, inspiring the development of early diagnostic, individualized, and precision therapeutic strategies for HCC.

HCC Micropeptides sORFs ncRNAs SEPs

SCI

英语

第一 ; 通讯

GuangDong Basic and Applied Basic Research Foundation[2022A1515110283] ; Shenzhen Key Medical Discipline Construction Fund[SZXK015] ; Training Program for cultivating clinical physician-scientists of Shenzhen People's Hospital[SYWGSJCYJ202203]

Oncology

Oncology

WOS:001188387200001

ELSEVIER IRELAND LTD

CLINICAL MEDICINE

Web of Science

Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1,Div Hepatobiliary & Pancreas Sur, Shenzhen Peoples Hosp,Dept Gen Surg,Clin Med Coll, Shenzhen 518020, Peoples R China

Zhang, Qiangnu,Liu, Liping. Novel insights into small open reading frame-encoded micropeptides in hepatocellular carcinoma: A potential breakthrough[J]. CANCER LETTERS,2024,587.

Zhang, Qiangnu,&Liu, Liping.(2024).Novel insights into small open reading frame-encoded micropeptides in hepatocellular carcinoma: A potential breakthrough.CANCER LETTERS,587.

Zhang, Qiangnu,et al."Novel insights into small open reading frame-encoded micropeptides in hepatocellular carcinoma: A potential breakthrough".CANCER LETTERS 587(2024).