In vivo NIR-II fluorescence imaging for biology and medicine

Wang, Feifei1; Zhong, Yeteng2; Bruns, Oliver3,4; Liang, Yongye5; Dai, Hongjie6,7,8

2024-03-01

10.1038/s41566-024-01391-5

NATURE PHOTONICS   影响因子和分区

1749-4885

1749-4893

["Owing to reduced light scattering and tissue autofluorescence, in vivo fluorescence imaging in the 1,000-3,000-nm near-infrared II (NIR-II) spectral range can afford non-invasive imaging at depths of millimetres within biological tissue. Infrared fluorescent probes labelled with antibodies or other targeting ligands also enable NIR-II molecular imaging at the single-cell level. Here we present recent developments in the design of fluorophores and probes emitting in the NIR-II window based on organic synthesis and nanoscience approaches. We also review advances in NIR-II wide-field and microscopy imaging modalities, with a focus on preclinical imaging and promising clinical translation case studies. Finally, we outline current issues and challenges for the wider adoption of NIR-II imaging in biomedical research and clinical imaging.","A review of NIR-II fluorescence imaging is presented, with a focus on fluorophores, probes and imaging techniques."]

SCI

英语

其他

U.S. Department of Health AMP; Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review)[NIH DP1-NS-105737]

Optics ; Physics

Optics ; Physics, Applied

WOS:001178071900001

NATURE PORTFOLIO

Web of Science

1.Univ Hong Kong, Dept Elect & Elect Engn, Hong Kong, Peoples R China
2.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China
3.Natl Ctr Tumor Dis NCT UCC Dresden, Dept Funct Imaging Surg Oncol, Dresden, Germany
4.Helmholtz Zentrum Munchen, Helmholtz Pioneer Campus, Neuherberg, Germany
5.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen, Peoples R China
6.Stanford Univ, Dept Chem & Biox, Stanford, CA 94305 USA
7.Univ Hong Kong, Dept Chem, Dept Mech Engn, Hong Kong, Peoples R China
8.Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China

Wang, Feifei,Zhong, Yeteng,Bruns, Oliver,et al. In vivo NIR-II fluorescence imaging for biology and medicine[J]. NATURE PHOTONICS,2024.

Wang, Feifei,Zhong, Yeteng,Bruns, Oliver,Liang, Yongye,&Dai, Hongjie.(2024).In vivo NIR-II fluorescence imaging for biology and medicine.NATURE PHOTONICS.

Wang, Feifei,et al."In vivo NIR-II fluorescence imaging for biology and medicine".NATURE PHOTONICS (2024).