The effect of spread through air spaces on postoperative recurrence-free survival in patients with multiple primary lung cancers

Xie, Hongsheng1; Dou, Shihua2; Huang, Xiaoxiang1; Wen, Yuxin3; Yang, Lin1,3

2024-03-05

10.1186/s12957-024-03351-3

WORLD JOURNAL OF SURGICAL ONCOLOGY   影响因子和分区

1477-7819

Purpose The purpose of the study was to investigate the effect of spread through air spaces (STAS) on the postoperative prognosis of patients with multiple primary lung cancers staged from IA to IB based on tumor size. Methods Clinicopathological and follow-up data of 122 patients with multiple primary lung cancers diagnosed at stages IA-IB and surgically treated at the Department of Thoracic Surgery, Shenzhen people's Hospital from January 2019 to December 2021 were retrospectively analyzed. The study involved 42 males and 80 females. STAS status was used to divide them into two groups (87 cases in STAS (-) and 35 cases in STAS (+)). A logistic regression analysis, univariate and multivariate Cox regression analysis, and Kaplan-Meier curves (K-M) were used to determine how STAS affected recurrence-free survival (RFS) in patients. Results STAS (+) had a significantly higher recurrence rate than STAS (-). STAS was predicted by smoking history (P = 0.044), main tumor diameter (P = 0.02), and solid nodules on chest CT (P = 0.02). STAS incidence was not significantly different between lobectomy and sublobar resection groups (P = 0.17). Solid nodules on CT, tumor diameter, vascular invasion, pleural invasion, and STAS were significant predictors of recurrence in the univariate Cox regression analysis. Tumor diameter, pleural invasion and STAS were significant prognostic factors for recurrence in the multivariate Cox regression analysis. Furthermore, STAS (+) group was at greater risk of recurrence than STAS (-) group (34% vs. 0%, P < 0.05).. Conclusion Stage IA-IB multiple primary lung cancer patients with STAS (+) had a higher recurrence rate and a shorter overall survival rate.

Spread through air spaces Multiple primary lung cancer Recurrence-free survival Retrospective cohort study

SCI

英语

通讯

Shenzhen Science and Technology RD Fund[20190801095354960]

Oncology ; Surgery

Oncology ; Surgery

WOS:001180219100001

BMC

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
2.Hainan Med Coll, Affiliated Hosp 1, Dept Thorac Surg, Haikou, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Thorac Surg,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China

Xie, Hongsheng,Dou, Shihua,Huang, Xiaoxiang,et al. The effect of spread through air spaces on postoperative recurrence-free survival in patients with multiple primary lung cancers[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2024,22(1).

Xie, Hongsheng,Dou, Shihua,Huang, Xiaoxiang,Wen, Yuxin,&Yang, Lin.(2024).The effect of spread through air spaces on postoperative recurrence-free survival in patients with multiple primary lung cancers.WORLD JOURNAL OF SURGICAL ONCOLOGY,22(1).

Xie, Hongsheng,et al."The effect of spread through air spaces on postoperative recurrence-free survival in patients with multiple primary lung cancers".WORLD JOURNAL OF SURGICAL ONCOLOGY 22.1(2024).