RSPO2-associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer

Peng, Quanzhou1,2; Cao, Tianfeng1,3; Yang, Xue4; Ye, Zhujia5; Wang, Jun5; Chen, Shang1; Yu, Yanqi1; Yu, Yingdian1; Xue, Wenyuan1; Chen, Zhiwei5; Fan, Jianbing1,5

2024-03-01

10.1002/tox.24209

ENVIRONMENTAL TOXICOLOGY   影响因子和分区

1520-4081

1522-7278

["Background: Esophageal cancer is a highly aggressive malignancy with limited treatment options and poor prognosis. The identification of novel molecular subtypes and therapeutic targets is crucial for improving clinical outcomes.","Method: In this study, we investigated the role of R-spondin 2 (RSPO2) in esophageal cancer and its association with mitochondrial metabolism. Using bioinformatics analysis of publicly available datasets, we identified a panel of RSPO2-related mitochondrial metabolism genes and their expression patterns in esophageal cancer. Based on these genes, we stratified esophageal cancer patients into distinct molecular subtypes with different survival rates, immune cell infiltration profiles, and drug sensitivities.","Results: Our findings suggest that RSPO2-related mitochondrial metabolism genes may serve as potential therapeutic targets and prognostic markers for esophageal cancer. These genes play an important role in the prognosis, immune cell infiltration and drug sensitivity of esophageal cancer.","Conclusion: The identified molecular subtypes provide valuable insights into the underlying molecular mechanisms of esophageal cancer and could guide personalized treatment strategies in the future."]

esophageal cancer mitochondrial metabolism molecular subtypes RSPO2 therapeutic targets

SCI ; EI

英语

其他

Environmental Sciences & Ecology ; Toxicology ; Water Resources

Environmental Sciences ; Toxicology ; Water Resources

WOS:001185852500001

WILEY

ENVIRONMENT/ECOLOGY

Web of Science

1.Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Dept Pathol, Shenzhen, Peoples R China
3.Xian 1 Hosp, Dept Pathol, Xian, Peoples R China
4.Shandong First Med Univ, Shandong Prov Hosp, Med Insurance Off, Jinan, Peoples R China
5.AnchorDX Med Co Ltd, Guangzhou, Peoples R China

Peng, Quanzhou,Cao, Tianfeng,Yang, Xue,et al. RSPO2-associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer[J]. ENVIRONMENTAL TOXICOLOGY,2024.

Peng, Quanzhou.,Cao, Tianfeng.,Yang, Xue.,Ye, Zhujia.,Wang, Jun.,...&Fan, Jianbing.(2024).RSPO2-associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer.ENVIRONMENTAL TOXICOLOGY.

Peng, Quanzhou,et al."RSPO2-associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer".ENVIRONMENTAL TOXICOLOGY (2024).