南方科技大学知识苑(SUSTech KC): Cytokine IL-5 and HGF: combined prediction of non-/low immune response to hepatitis B vaccination at birth in infants born to HBsAg-positive mothers

题名	Cytokine IL-5 and HGF: combined prediction of non-/low immune response to hepatitis B vaccination at birth in infants born to HBsAg-positive mothers
作者	Ou, Guanyong1,2 ; Qing, Ling 1,3; Zhang, Li 1,3 ; Yang, Yang 1 ; Ye, Guoguo 1; Peng, Ling1 ; Li, Yanjie 1; Yang, Liuqing1 ; Liu, Yingxia 1
通讯作者	Liu, Yingxia
发表日期	2024-03-01
DOI	10.3389/fcimb.2024.1332666
发表期刊	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 影响因子和分区
ISSN	2235-2988
卷号	14
摘要	Background The immune response to hepatitis B vaccine may be influenced by numerous factors, and patients with non/low response re-exposed to hepatitis B virus remain susceptible. Thus, a better understanding of the underlying mechanisms of non/low immune response in infants born to Hepatitis B surface antigen (HBsAg)-positive mothers is essential.Methods 100 infants born to HBsAg-positive mothers from 2015 to 2020 were enrolled in the study, further divided into the non/low response group (n=13) and the moderate strong response group (n=87) based on the quantification of hepatitis B surface antibody at 12 months of age. The differential expression of 48 immune-related cytokines in the two groups was compared and analyzed in detail. The key cytokines were further identified and clinically predictive models were developed.Results We found that 13 cytokines were lowly expressed and one cytokine was highly expressed in the non/low response group, compared with the moderate strong response group at birth. In addition, 9 cytokines were lowly expressed and one cytokine was highly expressed in the non/low response group at 12 months of age. Furthermore, we found that IL-5 and HGF were promising predictors for predicting the immunization response to hepatitis B vaccine in infants, and the combination of the two cytokines showed the best predictive efficiency, with an area under the curve (AUC) value of 0.844.Conclusion The present study provides a theoretical basis on cytokines for developing and implementing effective immunotherapies against non/low immune response in infants born to HBsAg-positive mothers.
关键词	hepatitis B vaccine immune response infant cytokine IL-5 HGF non/low response
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
WOS研究方向	Immunology ; Microbiology
WOS类目	Immunology ; Microbiology
WOS记录号	WOS:001184927300001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788944
专题	南方科技大学第二附属医院南方科技大学医学院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, State Key Discipline Infect Dis,Hosp 2, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 3.Univ South China, Grad Collaborat Training Base, Hengyang Med Sch, Shenzhen Peoples Hosp 3, Hengyang, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院; 南方科技大学医学院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Ou, Guanyong,Qing, Ling,Zhang, Li,et al. Cytokine IL-5 and HGF: combined prediction of non-/low immune response to hepatitis B vaccination at birth in infants born to HBsAg-positive mothers[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2024,14.
APA	Ou, Guanyong.,Qing, Ling.,Zhang, Li.,Yang, Yang.,Ye, Guoguo.,...&Liu, Yingxia.(2024).Cytokine IL-5 and HGF: combined prediction of non-/low immune response to hepatitis B vaccination at birth in infants born to HBsAg-positive mothers.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,14.
MLA	Ou, Guanyong,et al."Cytokine IL-5 and HGF: combined prediction of non-/low immune response to hepatitis B vaccination at birth in infants born to HBsAg-positive mothers".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 14(2024).