南方科技大学知识苑(SUSTech KC): Recent advances of single-cell RNA sequencing in toxicology research: Insight into hepatotoxicity and nephrotoxicity

题名	Recent advances of single-cell RNA sequencing in toxicology research: Insight into hepatotoxicity and nephrotoxicity
作者	Chen, Junhui1 ; Wu, Jiangpeng 1; Bai, Yunmeng1 ; Yang, Chuanbin 1; Wang, Jigang 1,2,3
通讯作者	Yang, Chuanbin; Wang, Jigang
发表日期	2024-03-01
DOI	10.1016/j.cotox.2024.100462
发表期刊	CURRENT OPINION IN TOXICOLOGY 影响因子和分区
ISSN	2468-2020
卷号	37
摘要	The advanced single -cell RNA sequencing (scRNA-seq) technology enables the measurement of gene expression levels and identification of cell -specific markers in individual cells, and the revealing of cell types, providing valuable insights into cell behavior. ScRNA-seq has emerged as an effective method for detecting rare cell populations, cellular heterogeneity, and cell -to -cell crosstalk under physiology and pathology conditions, thereby advancing the revolution of toxicology research. In this review, we first briefly introduce the concept of hepatotoxicity and nephrotoxicity, along with their underlying mechanisms. We then summarize the singlecell sequencing technology, with an emphasis on single -cell isolation techniques, particularly for the most used dropletbased methods. Finally, we review the recent advances in the application of single -cell RNA sequencing in studying hepatotoxicity and nephrotoxicity. Overall, this review provides a comprehensive understanding of the recent advances in hepatotoxicity and nephrotoxicity studies at a single -cell resolution.
关键词	Hepatotoxicity Nephrotoxicity scRNA sequencing Application of scRNA sequencing.
相关链接	[来源记录]
收录类别	ESCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Shenzhen Science and Technology Innovation Commission["JCYJ20210324114014039","JCYJ20210324115800001","JCYJ20220818102613029"] ; Shenzhen Medical Research Fund[B2302051] ; Shenzhen Governmental Sustainable Development Fund[KCXFZ20201221173612034] ; National Natural Science Foundation of China[82374063] ; Shenzhen key Laboratory of Kidney Diseases[ZDSYS201504301616234] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP001]
WOS研究方向	Toxicology
WOS类目	Toxicology
WOS记录号	WOS:001174028700001
出版者	ELSEVIER
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/788951
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen Clin Res Ctr Geriatr, Shenzhen 518020, Peoples R China 2.China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Assurance & Sustainable Use Dao, Beijing 100700, Peoples R China 3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Chen, Junhui,Wu, Jiangpeng,Bai, Yunmeng,et al. Recent advances of single-cell RNA sequencing in toxicology research: Insight into hepatotoxicity and nephrotoxicity[J]. CURRENT OPINION IN TOXICOLOGY,2024,37.
APA	Chen, Junhui,Wu, Jiangpeng,Bai, Yunmeng,Yang, Chuanbin,&Wang, Jigang.(2024).Recent advances of single-cell RNA sequencing in toxicology research: Insight into hepatotoxicity and nephrotoxicity.CURRENT OPINION IN TOXICOLOGY,37.
MLA	Chen, Junhui,et al."Recent advances of single-cell RNA sequencing in toxicology research: Insight into hepatotoxicity and nephrotoxicity".CURRENT OPINION IN TOXICOLOGY 37(2024).