Natural Fat Nanoemulsions for Enhanced Optical Coherence Tomography Neuroimaging and Tumor Imaging in the Second Near-Infrared Window

Geng, Xiaorui1,2; Liang, Xiao1,2,3; Liu, Yubin4; Chen, Yuhao1,2; Xue, Bin1,2,5,6; Wei, Xianyuan1,2; Yuan, Zhen1,2

2024-03-11

10.1021/acsnano.4c01204

ACS NANO   影响因子和分区

1936-0851

1936-086X

Optical coherence tomography (OCT) imaging mainly uses backscattered light to visualize the structural and functional information on biological tissues. In particular, OCT angiography can not only map the capillary networks but also capture the blood flow in the tissue microenvironment, making it a good candidate for neuroimaging and tumor imaging in vivo and in real time. To further improve the detection accuracy of cancer or brain disorders, it is essential to develop a natural and nontoxic contrast agent for enhanced OCT imaging in the second near-infrared (NIR-II) window. In this study, a superior biocompatible and highly scattering NIR-II fat nanoemulsion was constructed to improve OCT imaging contrast and depth for monitoring the vascular network changes of the cerebral cortex or tumor. In vivo experimental results demonstrated that a natural fat nanoemulsion can serve as an excellent probe for enhanced OCT neuroimaging and tumor imaging.

optical coherence tomography angiography nanoemulsion tumor imaging neuroimaging

SCI ; EI

英语

其他

Natural Science Foundation of Guangdong Province["MYRG-GRG2023-00038-FHS","MYRG2022-00054-FHS"] ; University of Macau["FDCT 0020/2019/AMJ","FDCT 0048/2021/AGJ"] ; Macao Science and Technology Development Fund[EF017/FHS-YZ/2021/GDST]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001184716200001

AMER CHEMICAL SOC

Web of Science

1.Univ Macau, Fac Hlth Sci, Canc Ctr, Taipa 999078, Macau, Peoples R China
2.Univ Macau, Ctr Cognit & Brain Sci, Taipa 999078, Macau, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
4.Fujian Normal Univ, Coll Photon & Elect Engn, Fuzhou 350117, Peoples R China
5.Shenzhen Technol Univ, Ctr Adv Mat Diagnost Technol, Shenzhen Key Lab Ultraintense Laser & Adv Mat Tech, Shenzhen 518118, Peoples R China
6.Shenzhen Technol Univ, Coll Engn Phys, Shenzhen 518118, Peoples R China

Geng, Xiaorui,Liang, Xiao,Liu, Yubin,et al. Natural Fat Nanoemulsions for Enhanced Optical Coherence Tomography Neuroimaging and Tumor Imaging in the Second Near-Infrared Window[J]. ACS NANO,2024,18(12).

Geng, Xiaorui.,Liang, Xiao.,Liu, Yubin.,Chen, Yuhao.,Xue, Bin.,...&Yuan, Zhen.(2024).Natural Fat Nanoemulsions for Enhanced Optical Coherence Tomography Neuroimaging and Tumor Imaging in the Second Near-Infrared Window.ACS NANO,18(12).

Geng, Xiaorui,et al."Natural Fat Nanoemulsions for Enhanced Optical Coherence Tomography Neuroimaging and Tumor Imaging in the Second Near-Infrared Window".ACS NANO 18.12(2024).