Wireless Bioelectronics for In Vivo Pressure Monitoring with Mechanically-Compliant Hydrogel Biointerfaces

Lin, Jingsen1; Chen, Xingmei1; Zhang, Pei1; Xue, Yu1; Feng, Yinghui1; Ni, Zhipeng1; Tao, Yue1; Wang, Yafei1; Liu, Ji1,2,3

2024-06-01

10.1002/adma.202400181

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

["Recent electronics-tissues biointefacing technology has offered unprecedented opportunities for long-term disease diagnosis and treatment. It remains a grand challenge to robustly anchor the pressure sensing bioelectronics onto specific organs, since the periodically-varying stress generated by normal biological processes may pose high risk of interfacial failures. Here, a general yet reliable approach is reported to achieve the robust hydrogel interface between wireless pressure sensor and biological tissues/organs, featuring highly desirable mechanical compliance and swelling resistance, despite the direct contact with biofluids and dynamic conditions. The sensor is operated wirelessly through inductive coupling, characterizing minimal hysteresis, fast response times, excellent stability, and robustness, thus allowing for easy handling and eliminating the necessity for surgical extraction after a functional period. The operation of the wireless sensor has been demonstrated with a custom-made pressure sensing model and in vivo intracranial pressure monitoring in rats. This technology may be advantageous in real-time post-operative monitoring of various biological inner pressures after the reconstructive surgery, thus guaranteeing the timely treatment of lethal diseases.","Wireless Bioelectronics for In Vivo Pressure with Hydrogel Interfaces: Wireless pressure sensors are anchored onto the biological tissues/organs with a mechanically-compliant and robust hydrogel interface, which could effectively alleviate foreign body responses and mitigate the interfacial mechanical mismatch, and enhance the efficacy of the wireless pressure sensing. image"]

bioelectronics hydrogel bioadhesion mechanical compliance pressure sensor wireless

SCI ; EI

英语

第一 ; 通讯

STI[2022ZD0209500] ; Natural Science Foundation of Guangdong Province["2022A1515010152","2021A1515110735"] ; Basic Research Program of Shenzhen["JCYJ20210324105211032","GJHZ20210705141809030","JCYJ20230807093419041"] ; Scientific Research Platforms and Projects of University of Guangdong Provincial Education Office[2022ZDZX3019] ; Key Talent Recruitment Program of Guangdong Province[2019QN01Y576] ; Science, Technology and Innovation Commission of Shenzhen Municipality[ZDSYS20220527171403009] ; null[52373139]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001184683200001

WILEY-V C H VERLAG GMBH

20241115751285

Biological organs ; Diagnosis ; Diseases ; Electromagnetic induction ; Failure (mechanical) ; Histology ; Hydrogels ; Inductive sensors ; Inductively coupled plasma ; Surgery ; Tissue

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Electricity: Basic Concepts and Phenomena:701.1 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Control Instrumentation:732.2 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Plasma Physics:932.3 ; Pressure Measuring Instruments:944.3

MATERIALS SCIENCE

Web of Science

1.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Key Lab Intelligent Robot & Flexible Mfg, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Human Augmentat & Rehabil R, Shenzhen 518055, Peoples R China

Lin, Jingsen,Chen, Xingmei,Zhang, Pei,et al. Wireless Bioelectronics for In Vivo Pressure Monitoring with Mechanically-Compliant Hydrogel Biointerfaces[J]. ADVANCED MATERIALS,2024,36(26).

Lin, Jingsen.,Chen, Xingmei.,Zhang, Pei.,Xue, Yu.,Feng, Yinghui.,...&Liu, Ji.(2024).Wireless Bioelectronics for In Vivo Pressure Monitoring with Mechanically-Compliant Hydrogel Biointerfaces.ADVANCED MATERIALS,36(26).

Lin, Jingsen,et al."Wireless Bioelectronics for In Vivo Pressure Monitoring with Mechanically-Compliant Hydrogel Biointerfaces".ADVANCED MATERIALS 36.26(2024).