| 题名 | Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats |
| 作者 | |
| 通讯作者 | Zhang, Lei; Hao, Lirong |
| 发表日期 | 2024-12-31
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| DOI | |
| 发表期刊 | |
| ISSN | 0886-022X
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| EISSN | 1525-6049
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| 卷号 | 46期号:1 |
| 摘要 | Diabetic kidney disease (DKD) is a leading factor in end-stage renal disease. The complexity of its pathogenesis, combined with the limited treatment efficacy, necessitates deeper insights into potential causes. Studies suggest that ferroptosis-driven renal tubular damage contributes to DKD's progression, making its counteraction a potential therapeutic strategy. Quercetin, a flavonoid found in numerous fruits and vegetables, has demonstrated DKD mitigation in mouse models, though its protective mechanism remains ambiguous. In this study, we delved into quercetin's potential anti-ferroptotic properties, employing a DKD rat model and high glucose (HG)-treated renal tubular epithelial cell models. Our findings revealed that HG prompted unusual ferroptosis activation in renal tubular epithelial cells. However, quercetin counteracted this by inhibiting ferroptosis and activating NFE2-related factor 2 (Nrf2) expression in both DKD rats and HG-treated HK-2 cells, indicating its renal protective role. Further experiments, both in vivo and in vitro, validated that quercetin stimulates Nrf2. Thus, our research underscores quercetin's potential in DKD treatment by modulating the ferroptosis process via activating Nrf2 in a distinct DKD rat model, offering a fresh perspective on quercetin's protective mechanisms. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | National Natural Science Foundation of China[8187031226]
; Shenzhen Science Technology and Innovation Commission (SZSTI)[JCYJ20210324103801005]
; Sub-project funds for technology research and development and creative design in Nanshan District, Shenzhen[NS2021001]
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| WOS研究方向 | Urology & Nephrology
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| WOS类目 | Urology & Nephrology
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| WOS记录号 | WOS:001184011700001
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| 出版者 | |
| ESI学科分类 | CLINICAL MEDICINE
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：9
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/788969 |
| 专题 | 南方科技大学医院 |
| 作者单位 | 1.Harbin Med Univ, Affiliated Hosp 1, Dept Nephropathy & Hemodialysis, Harbin, Heilongjiang, Peoples R China 2.Southern Univ Sci & Technol Hosp, Dept Nephropathy, Shenzhen, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 1, Dept Pathol, Harbin, Heilongjiang, Peoples R China 4.Harbin Med Univ, Dept Nephropathy & Hemodialysis, Affiliated Hosp 1, 23,Youzheng St, Harbin 150000, Heilongjiang, Peoples R China |
| 通讯作者单位 | 南方科技大学医院 |
| 推荐引用方式 GB/T 7714 |
Zhang, Lei,Wang, Xingzhi,Chang, Liang,et al. Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats[J]. RENAL FAILURE,2024,46(1).
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| APA |
Zhang, Lei.,Wang, Xingzhi.,Chang, Liang.,Ren, Yiqun.,Sui, Manshu.,...&Hao, Lirong.(2024).Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats.RENAL FAILURE,46(1).
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| MLA |
Zhang, Lei,et al."Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats".RENAL FAILURE 46.1(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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