Microvascular Disease, Cardiovascular Health, and Risk of Coronary Heart Disease in Type 2 Diabetes: A UK Biobank Study

Chen, Guo-Chong1; Hukportie, Daniel Nyarko2; Liu, Yu-Jie1; Wang, Hai-Peng3; Qin, Li-Qiang1; Fan, Wei-Dong4; Li, Fu-Rong4,5,6; Wu, Xian-Bo4,7

2024-02-01

10.1210/clinem/dgae100

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   影响因子和分区

0021-972X

1945-7197

Context The interplay between cardiovascular health metrics (CVHMs) and microvascular disease (MVD) in relation to the risk of incident coronary heart disease (CHD) among individuals with type 2 diabetes mellitus (T2DM) remains to be evaluated.Objective To investigate the role of MVD and CVHMs in the development of CHD among T2DM.Design We included 19 664 participants with T2DM from the UK Biobank who had CVHM data and were free of CHD during recruitment. CVHMs were defined based on 5 behavioral (body mass index, diet, sleep duration, smoking, and regular exercise) and 3 biological (glycemic control, hyperlipidemia, and hypertension) factors. MVD was defined as the presence of retinopathy, peripheral neuropathy, or chronic kidney disease. Hazard ratio (HR) and 95% CI of CHD were estimated by multivariable Cox regression models.Results There were 3252 incident cases of CHD recorded after a median follow-up of 12.3 years. After multivariable adjustment, each MVD was separately associated with risk of CHD, and those who had 1 or >= 2 MVD had a 27% and an 87% increased risk of developing CHD, respectively. Each unfavorable CVHM was associated with a higher risk of CHD. As compared with MVD-free participants who had ideal CVHMs, those who had >= 2 MVD and had poor CVHMs were at particularly high risk of incident CHD (HR = 4.58; 95% CI: 3.58, 5.86), similarly when considering behavioral CVH or biological CVH separately. On an additive scale, there was a positive statistically significant interaction between number of MVD and CVHMs.Conclusion Coexistence of multiple MVDs was associated with a substantially higher risk of CHD among individuals with T2DM. Such association may be amplified by unfavorable CVHMs.

microvascular disease coronary heart disease cardiovascular health metrics biological risk factors behavioral risk factors

SCI

英语

通讯

National Natural Science Foundation of China[60009]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:001181974700001

ENDOCRINE SOC

CLINICAL MEDICINE

Web of Science

1.Soochow Univ, Suzhou Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou 215031, Peoples R China
2.Coll Community Hlth Nursing, Dept Publ Hlth, POB 273, Winneba, Central, Ghana
3.Soochow Univ, Affiliated Hosp 1, Dept Cardiol, Suzhou 215006, Peoples R China
4.Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou 510515, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen 518055, Peoples R China
6.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, 1088 Xueyuan Ave, Shenzhen 518055, Peoples R China
7.Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, 1023 Shatai South Rd, Guangzhou 510515, Guangdong, Peoples R China

Chen, Guo-Chong,Hukportie, Daniel Nyarko,Liu, Yu-Jie,et al. Microvascular Disease, Cardiovascular Health, and Risk of Coronary Heart Disease in Type 2 Diabetes: A UK Biobank Study[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2024.

Chen, Guo-Chong.,Hukportie, Daniel Nyarko.,Liu, Yu-Jie.,Wang, Hai-Peng.,Qin, Li-Qiang.,...&Wu, Xian-Bo.(2024).Microvascular Disease, Cardiovascular Health, and Risk of Coronary Heart Disease in Type 2 Diabetes: A UK Biobank Study.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM.

Chen, Guo-Chong,et al."Microvascular Disease, Cardiovascular Health, and Risk of Coronary Heart Disease in Type 2 Diabetes: A UK Biobank Study".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2024).