Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy

Xue, Qiang1,2; Zeng, Silue2,3; Ren, Yaguang2; Pan, Yingying2,4; Chen, Jianhai2; Chen, Ningbo2,5; Wong, Kenneth K. Y.5; Song, Liang2; Fang, Chihua3; Guo, Jinhan1; Xu, Jinfeng1; Liu, Chengbo2; Zeng, Jie4; Sun, Litao6; Zhang, Hai; Chen, Jingqin2

2024

10.1364/BOE.499286

BIOMEDICAL OPTICS EXPRESS   影响因子和分区

2156-7085

Hypoxia is a critical tumor microenvironment (TME) component. It significantly impacts tumor growth and metastasis and is known to be a major obstacle for cancer therapy. Integrating hypoxia modulation with imaging -based monitoring represents a promising strategy that holds the potential for enhancing tumor theranostics. Herein, a kind of nanoenzyme Prussian blue (PB) is synthesized as a metal -organic framework (MOF) to load the second near -infrared (NIR-II) small molecule dye IR1061, which could catalyze hydrogen peroxide to produce oxygen and provide a photothermal conversion element for photoacoustic imaging (PAI) and photothermal therapy (PTT). To enhance stability and biocompatibility, silica was used as a coating for an integrated nanoplatform (SPI). SPI was found to relieve the hypoxic nature of the TME effectively, thus suppressing tumor cell migration and downregulating the expression of heat shock protein 70 (HSP70), both of which led to an amplified NIR-II PTT effect in vitro and in vivo, guided by the NIR-II PAI. Furthermore, label -free multi -spectral PAI permitted the real-time evaluation of SPI as a putative tumor treatment. A clinical histological analysis confirmed the amplified treatment effect. Hence, SPI combined with PAI could offer a new approach for tumor diagnosing, treating, and monitoring. (c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

SCI ; EI

英语

第一

Basic and Applied Basic Research Foundation of Guangdong Province[2020A1515010978] ; Shenzhen Science and Technology Innovation Program["JCYJ20180228164437735","JCYJ20190806150001764","JCYJ20220818101 403008"] ; National Natural Science Foundation of China["92059108","2020YFA0908800","82122034"] ; National Key Research and Development Program of China["2021YFE0202200","2022YFE0132300","81927807"] ; null[82172008]

Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging

Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging

WOS:001171383300001

Optica Publishing Group

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Clin Coll 2, Dept Ultrasound,Affiliated Hosp 1,Shenzhen Peoples, Shenzhen 518020, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Biomed Opt & Mol Imaging, Key Lab Biomed Imaging Sci & Syst, Shenzhen 518055, Peoples R China
3.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Med Ultrason, Guangzhou, Peoples R China
5.Univ Hong Kong, Dept Elect & Elect Engn, Hong Kong, Peoples R China
6.Hangzhou Med Coll, Affiliated Peoples Hosp Hangzhou Med Coll, Canc Ctr, Dept Ultrasound Med,Affiliated Peoples Hosp, Hangzhou 310014, Peoples R China

Xue, Qiang,Zeng, Silue,Ren, Yaguang,et al. Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy[J]. BIOMEDICAL OPTICS EXPRESS,2024,15(1).

Xue, Qiang.,Zeng, Silue.,Ren, Yaguang.,Pan, Yingying.,Chen, Jianhai.,...&Chen, Jingqin.(2024).Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy.BIOMEDICAL OPTICS EXPRESS,15(1).

Xue, Qiang,et al."Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy".BIOMEDICAL OPTICS EXPRESS 15.1(2024).