Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease

Guo, Shuyuan1; Zhang, Zhuxia1,2; Xu, Bingxuan1; Wang, Mengxin3; Fan, Taojian4; Zhong, Xinliang5; Hu, Azhen1; Hu, Die1; Luo, Lan1; Lin, Shuping1; Wang, Linlin1,6; Yao, Rongquan1; Huang, Jiabao1; Hu, Huiying1; Shuai, Xintao7; Shi, Jie1,8,9; Chen, Yun1; Zheng, Tingting1

2024-05-01

10.1002/adtp.202300254

ADVANCED THERAPEUTICS   影响因子和分区

2366-3987

["Parkinson's disease (PD) is a common chronic central nervous system disorder that reduces quality of life and increases mortality. Currently, the treatment of PD is limited due to the challenge of macromolecular drugs crossing the blood-brain barrier (BBB). Black phosphorus (BP) has antioxidant and anti-inflammatory effects and shows potential for neuroprotection. To solve the restriction of the BBB, innovative BP microbubbles (BP@MBs) combined with focused ultrasound (FUS) are constructed to facilitate BBB opening. Additionally, the biocompatibility and safety of BP@MBs with varying dimensions are investigated, including BP quantum dot microbubbles (BPQDs@MBs) and BP nanosheet microbubbles (BPNSs@MBs). The findings indicate that low concentrations of BP have good biosafety and that BPQDs@MBs exhibit better biocompatibility than BPNSs@MBs both in vitro and in vivo at the same concentrations. Moreover, a 6-hydroxydopamine (6-OHDA)-induced PD cell model and an animal model are established to verify the anti-PD effects of BPQDs@MBs and BPNSs@MBs. The results confirmed that BPQDs@MBs and BPNSs@MBs have antioxidant effects that reduced neuronal apoptosis and improved the motor symptoms of PD in rats. BPQDs@MBs combined with FUS may be a promising option for the clinical treatment of PD.","Black phosphorus microbubbles (BP@MBs) combined with focused ultrasound to open the blood-brain barrier for treatment of Parkinson's disease (PD) is constructed. BP@MBs have antioxidant effects, reduce neuronal apoptosis and improve motor symptoms of PD in vitro and in vivo. In particular, BP quantum dot microbubbles show better biocompatibility which are expected to become a new method and new drug for anti-PD. image"]

black phosphorus nanosheets (BPNSs) black phosphorus quantum dots (BPQDs) neuroinflammation oxidative damage Parkinson's disease (PD)

SCI

英语

其他

Science and Technology Planning Project of Shenzen Municipality["JCYJ20210324131402008","JCYJ20210324110211031","JCYJ20210324105614038","2022A1515010986"] ; Shenzhen Human Resources and Social Security Bureau, Shenzhen Postdoctoral Research Starting Grant["81871358","81901767","KCXFZ20200201101048774","JCYJ20200109140212277","2022A1515010296","SZSM202111011","SZXK051"]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:001179941500001

WILEY

Web of Science

1.Peking Univ, Dept Ultrasound, Shenzhen Key Lab Drug Addict & Medicat Safety, Inst Ultrason Med,Shenzhen Hosp,Shenzhen Peking Un, Shenzhen 518036, Guangdong, Peoples R China
2.Jinan Univ, Sch Environm, Lab Environm Med & Dev Toxicol, Guangdong Key Lab Environm Pollut & Hlth, Guangzhou 511443, Guangdong, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Beijing 100191, Bingjing Provin, Peoples R China
4.Shenzhen Univ, Inst Microscale Optoelect, Shenzhen 518060, Guangdong, Peoples R China
5.Southern Univ Sci & Technol Hosp, Dept Oncol, Shenzhen 518036, Guangdong, Peoples R China
6.Hubei Univ Med, Shiyan 442000, Hubei, Peoples R China
7.Sun Yat Sen Univ, Sch Mat Sci & Engn, PCFM Lab, Minist Educ, Guangzhou 510275, Guangdong, Peoples R China
8.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
9.Peking Univ, Beijing Key Lab Drug Dependence Res, Beijing 100191, Peoples R China

Guo, Shuyuan,Zhang, Zhuxia,Xu, Bingxuan,et al. Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease[J]. ADVANCED THERAPEUTICS,2024,7(5).

Guo, Shuyuan.,Zhang, Zhuxia.,Xu, Bingxuan.,Wang, Mengxin.,Fan, Taojian.,...&Zheng, Tingting.(2024).Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease.ADVANCED THERAPEUTICS,7(5).

Guo, Shuyuan,et al."Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease".ADVANCED THERAPEUTICS 7.5(2024).