Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report

Yang, Jinrong; Pan, Liping; Liu, Yaping; Wang, Yanrong

2024

10.2147/DNND.S451611

DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE   影响因子和分区

1179-9900

Myasthenia gravis (MG) is an autoimmune disease which can impact pregnancy. We describe a transient neonatal myasthenia gravis (TNMG) born to an asymptomatic mother aged 26. The newborn presented cyanosis and generalized muscular weakness quickly after birth. Nasal continuous positive airway pressure (nCPAP) ventilation was performed immediately. On day 3, detailed family history showed that the neonate's 50 -year -old maternal grandmother was diagnosed as ocular MG at the age of 40. Ryanodine receptor calcium release channel antibody (RyR-Ab) and acetylcholine receptor antibody (AChR-Ab) tested on day 5 were positive. However, neostigmine tests were negative for the neonate. Intravenous immunoglobulin (IVIG) and oral pyridostigmine were administered. The infant was weaned from the ventilator on day 7. On day 10, the neonate's asymptomatic mother was confirmed to have positive AChR-Ab either. The neonate regained the capability of bottle feeding on day 17 and discharged on day 26. Asymptomatic pregnant women with MG family history can also deliver infants who develop TNMG. Testing AChR antibodies in pregnant women with a family history of MG should be necessary as TNMG was a life -threatening disease. With timely diagnosis and accurate treatment, TNMG can be effectively relieved.

transient neonatal myasthenia gravis asymptomatic MG IVIG pyridostigmine

ESCI

英语

第一 ; 通讯

Foundation Shenzhen Third People's Hospital[22240G1034]

Neurosciences & Neurology

Clinical Neurology

WOS:001178842100001

DOVE MEDICAL PRESS LTD

Web of Science

Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Dept Neonatol, 29 Buji Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China

Yang, Jinrong,Pan, Liping,Liu, Yaping,et al. Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report[J]. DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE,2024,14.

Yang, Jinrong,Pan, Liping,Liu, Yaping,&Wang, Yanrong.(2024).Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report.DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE,14.

Yang, Jinrong,et al."Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report".DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE 14(2024).