南方科技大学知识苑(SUSTech KC): Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report

题名	Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report
作者	Yang, Jinrong; Pan, Liping; Liu, Yaping; Wang, Yanrong
通讯作者	Wang, Yanrong
发表日期	2024
DOI	10.2147/DNND.S451611
发表期刊	DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE 影响因子和分区
EISSN	1179-9900
卷号	14
摘要	Myasthenia gravis (MG) is an autoimmune disease which can impact pregnancy. We describe a transient neonatal myasthenia gravis (TNMG) born to an asymptomatic mother aged 26. The newborn presented cyanosis and generalized muscular weakness quickly after birth. Nasal continuous positive airway pressure (nCPAP) ventilation was performed immediately. On day 3, detailed family history showed that the neonate's 50 -year -old maternal grandmother was diagnosed as ocular MG at the age of 40. Ryanodine receptor calcium release channel antibody (RyR-Ab) and acetylcholine receptor antibody (AChR-Ab) tested on day 5 were positive. However, neostigmine tests were negative for the neonate. Intravenous immunoglobulin (IVIG) and oral pyridostigmine were administered. The infant was weaned from the ventilator on day 7. On day 10, the neonate's asymptomatic mother was confirmed to have positive AChR-Ab either. The neonate regained the capability of bottle feeding on day 17 and discharged on day 26. Asymptomatic pregnant women with MG family history can also deliver infants who develop TNMG. Testing AChR antibodies in pregnant women with a family history of MG should be necessary as TNMG was a life -threatening disease. With timely diagnosis and accurate treatment, TNMG can be effectively relieved.
关键词	transient neonatal myasthenia gravis asymptomatic MG IVIG pyridostigmine
相关链接	[来源记录]
收录类别	ESCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Foundation Shenzhen Third People's Hospital[22240G1034]
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology
WOS记录号	WOS:001178842100001
出版者	DOVE MEDICAL PRESS LTD
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/789007
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Dept Neonatol, 29 Buji Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Yang, Jinrong,Pan, Liping,Liu, Yaping,et al. Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report[J]. DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE,2024,14.
APA	Yang, Jinrong,Pan, Liping,Liu, Yaping,&Wang, Yanrong.(2024).Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report.DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE,14.
MLA	Yang, Jinrong,et al."Transient Neonatal Myasthenia Gravis Born to a Mother with Asymptomatic MG: A Case Report".DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE 14(2024).