南方科技大学知识苑(SUSTech KC): Reservoir of human immunodeficiency virus in the brain: New insights into the role of T cells

题名	Reservoir of human immunodeficiency virus in the brain: New insights into the role of T cells
作者	Zhang, Yingdong 1,2; Chu, Ming 1,2; Lu, Hongzhou 3
通讯作者	Chu, Ming; Lu, Hongzhou
发表日期	2023
DOI	10.32604/biocell.2023.030331
发表期刊	BIOCELL 影响因子和分区
ISSN	0327-9545
EISSN	1667-5746
卷号	47 期号:12
摘要	Human immunodeficiency virus (HIV) infection of the central nervous system (CNS) has attracted significant attention because it contributes to severe complications of acquired immunodeficiency syndrome (AIDS) and seriously impairs the life quality of infected patients. In this review, we briefly describe the latent infection of HIV in CNS and focus on the role of the important immune cells, such as T cells, in the formation and maintenance of the HIV reservoir in CNS. This review explores the mechanisms by which T cells enter CNS and establish latent infection of HIV in the CNS. In conclusion, we summarize the role of these cells in the interaction between HIV and CNS. With our better understanding of the underlying mechanisms, we propose future directions for the development of novel strategies to eliminate HIV reservoirs in the CNS based on cellular components.
关键词	Human immunodeficiency virus Central nervous system Reservoir Latent infection T cells
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Shenzhen Science and Technology Innovation Program["JCYJ20210324131607019","KCXFZ20211020163544002"]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:001167621500003
出版者	TECH SCIENCE PRESS
ESI学科分类	BIOLOGY & BIOCHEMISTRY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/789011
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.Southern Univ Sci & Technol, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Shenzhen 518055, Peoples R China 2.Second Affiliated Hosp, Sch Med, Shenzhen 518000, Peoples R China 3.Shenzhen Third Peoples Hosp, Dept Infect Dis, Natl Clin Res Ctr Infect Dis, Shenzhen 518000, Peoples R China
第一作者单位	南方科技大学医学院; 南方科技大学第二附属医院
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
第一作者的第一单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Zhang, Yingdong,Chu, Ming,Lu, Hongzhou. Reservoir of human immunodeficiency virus in the brain: New insights into the role of T cells[J]. BIOCELL,2023,47(12).
APA	Zhang, Yingdong,Chu, Ming,&Lu, Hongzhou.(2023).Reservoir of human immunodeficiency virus in the brain: New insights into the role of T cells.BIOCELL,47(12).
MLA	Zhang, Yingdong,et al."Reservoir of human immunodeficiency virus in the brain: New insights into the role of T cells".BIOCELL 47.12(2023).